Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Antifungal Activity of Capric Acid, Nystatin, and Fluconazole and Their In Vitro Interactions Against Candida Isolates from Neonatal Oral Thrush

Sun Dec 4 02:17:57 2022

(2020) Antifungal Activity of Capric Acid, Nystatin, and Fluconazole and Their In Vitro Interactions Against Candida Isolates from Neonatal Oral Thrush. Assay and Drug Development Technologies. pp. 195-201. ISSN 1540-658X

Full text not available from this repository.

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

Due to the increasing resistance of various Candida species to azole drugs, particularly fluconazole, it would be of significant importance to look for alternative therapies. The aim of this study was to investigate the antifungal activity of capric acid and its in vitro interactions with nystatin and fluconazole against Candida isolates. A total of 40 Candida isolates (C. albicans, 36; C. kefyr, 2; C. tropicalis, 1; C. glabrata, 1) collected from the oral cavity of neonates with oropharyngeal candidiasis and a reference strain of C. albicans (ATCC 10231) were used in this study. Antifungal activity of capric acid and two comparator antifungal drugs, namely fluconazole and nystatin, was tested according to CLSI M27-A3/M60 method. The in vitro interaction between capric acid with fluconazole and nystatin was determined following a checkerboard method and results were interpreted using fractional inhibitory concentration index. Nystatin had the lowest minimum inhibitory concentrations (range, 0.125-8 mu g/mL; geometric mean GM, 0.6229 mu g/mL) followed by fluconazole (range, 0.5-16 mu g/mL; GM, 1.9011 mu g/mL) and capric acid (range, 128-2,048 mu g/mL; GM, 835.9756 mu g/mL). When tested in combination, capric acid with fluconazole demonstrated synergistic, indifferent, and antagonistic interactions in 3 (7.317%), 24 (58.536%), and 14 (34.146%) cases, respectively. For combination of capric acid with nystatin, synergistic, indifferent, and antagonistic interactions were observed in 1 (2.439%), 19 (46.341%), and 21 (51.219%) cases, respectively. All cases of synergistic interactions were against resistant or susceptible dose-dependent isolates. Fluconazole, nystatin, and capric acid seem to be more effective when they are used alone compared with their combination. However, their combination might be effective on resistant isolates.

Item Type: Article
Creators:
CreatorsEmail
Khalandi, H.UNSPECIFIED
Masoori, L.UNSPECIFIED
Farahyar, S.UNSPECIFIED
Delbandi, A. A.UNSPECIFIED
Raiesi, O.UNSPECIFIED
Farzanegan, A.UNSPECIFIED
Khalandi, G.UNSPECIFIED
Mahmoudi, S.UNSPECIFIED
Erfanirad, T.UNSPECIFIED
Falahati, M.UNSPECIFIED
Keywords: antifungal agents capric acid probiotics Candida complementary therapies Saccharomyces boulardii antibiotic-associated diarrhea saccharomyces-boulardii resistance chlorhexidine prevention albicans Biochemistry & Molecular Biology Pharmacology & Pharmacy
Divisions:
Page Range: pp. 195-201
Journal or Publication Title: Assay and Drug Development Technologies
Journal Index: ISI
Volume: 18
Number: 4
Identification Number: https://doi.org/10.1089/adt.2020.971
ISSN: 1540-658X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2572

Actions (login required)

View Item View Item