Abstract

Today, due to the emergence and spread of multidrug-resistant bacteria that have caused many therapeutic problems for the medical systems, and the lack of production of effective antibiotics in the commercial field in recent years, physicians are increasingly interested in using older antibiotics such as fosfomycin. Besides, because of the relatively low bacterial resistance to fosfomycin and its broad spectrum of action, it seems to be a molecule of therapeutic interest in the era of infection treatment. This antibiotic is still effective against many multidrug-resistant and extensively drug-resistant bacteria by inhibiting the early stages of the cell wall assembly. In this review, we summarize the currently available data regarding pharmacokinetics and pharmacodynamics, mechanism of action, oral and parenteral use, susceptibility breakpoints, antibacterial activity, mechanisms and epidemiology of resistance, and adverse effects of fosfomycin.