Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Hepatoprotective and cytotoxicity properties of aqueous extract of Glycyrrhiza glabra in Wistar rats fed with high-fat diet

Thu Apr 18 23:41:02 2024

(2019) Hepatoprotective and cytotoxicity properties of aqueous extract of Glycyrrhiza glabra in Wistar rats fed with high-fat diet. Comparative Clinical Pathology. ISSN 16185641 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

The recent studies have shown the effect of ethnomedicinal plants on the treatment of fatty liver disease. The purpose of the experiment was to survey the remedial activity of Glycyrrhiza glabra aqueous extract on high-fat diet-induced hepatotoxicity in rats. The synthesized extract had great cell viability dose-dependently, and this method was found to be non-toxic for synthesizing G. glabra. In the study, a total of 10 rats were chosen as the negative control, and 40 rats were treated with a high-fat diet for 4 months. Then, the animals were randomly divided into five subgroups, including negative healthy control, untreated negative control, and three groups receiving the G. glabra aqueous extract at 20, 60, and 180 mg/kg concentrations. After 2 months, the rats were sacrificed, and blood and liver samples of them collected. Different groups of G. glabra could significantly (p ≤ 0.05) decrease the increased concentrations of ALP, AST, ALT, GGT, cholesterol, LDL, triglyceride, total and conjugated bilirubin, and glucose, and enhance HDL, total protein, albumin, SOD, and CAT as compared to the untreated group. Also, G. glabra reduced the degree of hepatic steatosis as compared to the untreated group. It appears that the G. glabra aqueous extract can treat fatty liver disease in rats without any side effect. © 2019, Springer-Verlag London Ltd., part of Springer Nature.

Item Type: Article
Creators:
CreatorsEmail
Goorani, S.UNSPECIFIED
Morovvati, H.UNSPECIFIED
Seydi, N.UNSPECIFIED
Almasi, M.UNSPECIFIED
Amiri-Paryan, A.UNSPECIFIED
Nazari, F.UNSPECIFIED
Zangeneh, M. M.UNSPECIFIED
Zangeneh, A.UNSPECIFIED
Keywords: Fatty liver disease Glycyrrhiza glabra Hepatoprotective activity
Divisions:
Journal or Publication Title: Comparative Clinical Pathology
Journal Index: Scopus
Identification Number: https://doi.org/10.1007/s00580-019-02939-6
ISSN: 16185641 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2518

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