Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Evaluation of cutaneous wound healing activity of Ocimum basilicum aqueous extract ointment in rats

Sat Jul 20 23:25:13 2024

(2019) Evaluation of cutaneous wound healing activity of Ocimum basilicum aqueous extract ointment in rats. Comparative Clinical Pathology. ISSN 16185641 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

The recent researches have revealed the potential of ethno-medicinal plants on the treatment of the cutaneous wound. The purpose of the study was to investigate the cutaneous wound healing property of aqueous extract of Ocimum basilicum. In our study, 120 Sprague-Dawley male rats were used. After creating the cutaneous wounds, the animals were randomly divided into four groups: untreated control, treatment with Eucerin ointment, treatment with 3 tetracycline ointment, and treatment with 3 O. basilicum aqueous extract ointment. On days 10, 20, and 30 after creating the wound, for biochemical and histopathological analysis of the cutaneous wound healing trend, a section was prepared from all dermal thicknesses. The data were analyzed by SPSS-22 software. O. basilicum aqueous extract ointment could significantly (p ≤ 0.05) reduce the levels of the wound area, total cell, and neutrophil, lymphocyte, and enhance the levels of wound contracture, hydroxyproline, hexosamine, hexuronic acid, and fibrocyte as compared to the basal ointment and control groups. In conclusion, the acquired findings showed the cutaneous wound healing property of O. basilicum aqueous extract ointment. © 2019, Springer-Verlag London Ltd., part of Springer Nature.

Item Type: Article
Creators:
CreatorsEmail
Zangeneh, M. M.UNSPECIFIED
Zangeneh, A.UNSPECIFIED
Seydi, N.UNSPECIFIED
Moradi, R.UNSPECIFIED
Keywords: Aqueous extract Cutaneous wound Ocimum basilicum Ointment
Divisions:
Journal or Publication Title: Comparative Clinical Pathology
Journal Index: Scopus
Identification Number: https://doi.org/10.1007/s00580-019-02988-x
ISSN: 16185641 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2502

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