Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

A nanocomposite consisting of reduced graphene oxide and electropolymerized β-cyclodextrin for voltammetric sensing of levofloxacin

Sat Dec 10 01:07:32 2022

(2019) A nanocomposite consisting of reduced graphene oxide and electropolymerized β-cyclodextrin for voltammetric sensing of levofloxacin. Microchimica Acta. ISSN 00263672 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

A glassy carbon electrode (GCE) was modified with a nanocomposite prepared from polymerized β-cyclodextrin (β-CD) and reduced graphene oxide (rGO). The modified GCE is shown to enable the voltammetric determination of traces of levofloxacin (LEV) by various electrochemical techniques. Experimental factors affecting the results including the amount of the substrates in preparation of the nanocomposite, accumulation time, the scan rate and pH value of the electrolyte were optimized. The modified GCE, best operated at a working potential of 1.00 V (vs. Ag/AgCl), has two linear response ranges, one for low LEV concentrations (100 pmol L−1 to 100 nmol L−1), and one for higher LEV concentrations (100 nmol L−1 to 100 μmol L−1). The limit of detection and sensitivity are calculated to be 30 pmol L−1 and 467.33 nA μmol L−1 cm−2, respectively. The modified GCE demonstrates a number of advantages such as high sensitivity and selectivity, low LOD, excellent reproducibility, high surface-to-volume ratio, and good electrocatalytic activity towards LEV. The sensor was successfully applied to the determination of LEV in spiked human serum samples. Figure not available: see fulltext.. © 2019, Springer-Verlag GmbH Austria, part of Springer Nature.

Item Type: Article
Creators:
CreatorsEmail
Ghanbari, M. H.UNSPECIFIED
Shahdost-fard, F.UNSPECIFIED
Khoshroo, A.UNSPECIFIED
Rahimi-Nasrabadi, M.UNSPECIFIED
Ganjali, M. R.UNSPECIFIED
Wysokowski, M.UNSPECIFIED
Rębiś, T.UNSPECIFIED
Żółtowska-Aksamitowska, S.UNSPECIFIED
Jesionowski, T.UNSPECIFIED
Rahimi, P.UNSPECIFIED
Joseph, Y.UNSPECIFIED
Ehrlich, H.UNSPECIFIED
Keywords: Antibacterial agent Electrochemical sensing Electropolymerization Nanocomposite
Divisions:
Journal or Publication Title: Microchimica Acta
Journal Index: Scopus
Volume: 186
Number: 7
Identification Number: https://doi.org/10.1007/s00604-019-3530-6
ISSN: 00263672 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2493

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