Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The effect of 1.2mg simvastatin mouthwash on the level of interleukin-6 in patients with chronic periodontitis

Sun Sep 25 11:44:41 2022

(2019) The effect of 1.2mg simvastatin mouthwash on the level of interleukin-6 in patients with chronic periodontitis. Indian Journal of Forensic Medicine and Toxicology. pp. 463-467. ISSN 09739122 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Various materials and methods are nowadays used as complementary therapies for leveling the root surface for the treatment of periodontal diseases. The present study was conducted to evaluate the efficacy of simvastatin mouthwash on the level of interleukin-6 as an inflammatory cytokine that is supposed to be effective in the development of chronic periodontitis. The present randomized, double-blind clinical trial was conducted on 40 patients with moderate to severe chronic periodontitis. Initially, scaling and leveling the root surfaces were conducted for all patients and necessary training was presented; subjects in the intervention group, in addition to scaling, received 1.2simvastatin mouthwash. The level of interleukin-6 was measured before and one month after intervention, and data was analyzed by SPSS using paired t-test and covariance analysis. After treatment, there turned out to be a significant decrease in the level of interleukin-6 in the intervention group compared to the control group (P <0.05). The findings of the present study showed an increase in the clinical efficacy of treatment of chronic periodontitis with oral administration of 1.2 mg simvastatin as complementary therapy with scaling and leveling of the root surface. © 2019, Indian Journal of Forensic Medicine and Toxicology. All rights reserved.

Item Type: Article
Creators:
CreatorsEmail
Roozegar, M. A.UNSPECIFIED
Abdi, Z.UNSPECIFIED
Matin, S.UNSPECIFIED
Khorshidi, A.UNSPECIFIED
Azizian, M.UNSPECIFIED
Keywords: Chronic Periodontitis Interleukin-6 Mouthwash Simvastatin
Divisions:
Page Range: pp. 463-467
Journal or Publication Title: Indian Journal of Forensic Medicine and Toxicology
Journal Index: Scopus
Volume: 13
Number: 3
Identification Number: https://doi.org/10.5958/0973-9130.2019.00243.3
ISSN: 09739122 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2490

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