Repository of Research and Investigative Information

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Ilam University of Medical Sciences

Pharmacological, biochemical, and histopathological evaluations of cutaneous wound healing property of Mentha piperita aqueous extract ointment

Wed Jun 19 10:48:05 2024

(2019) Pharmacological, biochemical, and histopathological evaluations of cutaneous wound healing property of Mentha piperita aqueous extract ointment. Comparative Clinical Pathology. pp. 1181-1190. ISSN 16185641 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

In our study, we evaluated cutaneous wound healing potential of Mentha piperita aqueous extract ointment in rats. In vivo design, after creating the cutaneous wound on the back of the rats, the animals were randomly divided into four groups: untreated control, treatment with Eucerin ointment, treatment with 3 tetracycline ointment, and treatment with 3 M. piperita aqueous extract ointment. The groups were treated for 30 days. For biochemical and histopathological analysis of the cutaneous wound healing trend, a 3 × 3 cm section was prepared from all dermal thicknesses on days 10, 20, and 30. The data were analyzed by SPSS-21 software. The use of M. piperita aqueous extract ointment in the treatment groups led to remarkable reduction (p < 0.05) in the levels of wound area, total cells, neutrophil, lymphocyte, and macrophage and remarkable increase (p < 0.05) in the levels of wound contracture, hydroxyl proline, hexosamine, hexuronic acid, fibrocyte, and the rate of fibrocyte to fibroblast compared with the control and basal ointment groups. According to the findings, M. piperita aqueous extract ointment can cure the cutaneous wound. © 2019, Springer-Verlag London Ltd., part of Springer Nature.

Item Type: Article
Creators:
CreatorsEmail
Zangeneh, M. M.UNSPECIFIED
Zangeneh, A.UNSPECIFIED
Moradi, R.UNSPECIFIED
Seydi, N.UNSPECIFIED
Keywords: Aqueous extract Cutaneous wound healing Mentha piperita
Divisions:
Page Range: pp. 1181-1190
Journal or Publication Title: Comparative Clinical Pathology
Journal Index: Scopus
Volume: 28
Number: 4
Identification Number: https://doi.org/10.1007/s00580-019-02989-w
ISSN: 16185641 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2487

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