Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Synthesis and antimicrobial study of 1,4-dihydropyrano2,3-cpyrazole derivatives in the presence of amino-functionalized silica-coated cobalt oxide nanostructures as catalyst

Wed May 22 09:38:57 2024

(2019) Synthesis and antimicrobial study of 1,4-dihydropyrano2,3-cpyrazole derivatives in the presence of amino-functionalized silica-coated cobalt oxide nanostructures as catalyst. Polyhedron. pp. 172-179. ISSN 02775387 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

In this research a series of pyranopyrazoles were efficiently synthesized via the one-pot four-component reactions of ethyl acetoacetate, hydrazinehydrate, aldehydes and malononitrile in the presence of Co3O4@SiO2-tNH2 nanocomposites as catalyst. This study offers many advantages including short reaction times, excellent yields, environmental friendly nature, simple purification techniques and economic availability of the catalyst. The structure and magnetic characteristics of the nanocatalyst were fully characterized by spectral techniques including TEM, FE-SEM, EDX, XRD, FT-IR and VSM analysis. The antibacterial and antifungal activities of pyranopyrazoles nanocomposite was investigated against gram positive, i.e., Staphylococcus aureus and methicillin resistance Staphylococcus aureus and gram negative bacteria i.e., Escherichia coli and Pseudomonas aeruginosa and candida albicans by disc diffusion and minimum inhibitory concentration (MIC) methods. The result of diameter of the observed inhibition zone and MIC showed that of derivatives synthesized, (4-Br), (4-F) and (2; 4-Cl) bromobenzaldehyde have the greatest effect on S. aureus. © 2019

Item Type: Article
Creators:
CreatorsEmail
Shahbazi, S.UNSPECIFIED
Ghasemzadeh, M. A.UNSPECIFIED
Shakib, P.UNSPECIFIED
Zolfaghari, M. R.UNSPECIFIED
Bahmani, M.UNSPECIFIED
Keywords: Anti microbial Antibacterial activities Derivatives synthesized Nanocomposites Staphylococcus aereus
Divisions:
Page Range: pp. 172-179
Journal or Publication Title: Polyhedron
Journal Index: Scopus
Volume: 170
Identification Number: https://doi.org/10.1016/j.poly.2019.04.063
ISSN: 02775387 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2484

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