Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Linezolid activity against clinical Gram-positive cocci with advanced antimicrobial drug resistance in Iran

Thu Oct 6 04:46:43 2022

(2017) Linezolid activity against clinical Gram-positive cocci with advanced antimicrobial drug resistance in Iran. Journal of Global Antimicrobial Resistance. pp. 200-203. ISSN 2213-7165

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Abstract

Objectives: The aim of the study was to investigate the linezolid activity against clinical Gram-positive cocci with advanced antimicrobial drug resistance. Methods: A collection of methicillin resistant Staphylococcus aureus (MRSA), vancomycin resistant enterococci (VRE), penicillin non-susceptible Streptococcus pneumoniae (PNSP), and group B streptococci (GBS) were isolated from various clinical samples. Antimicrobial susceptibility tests were done using standard methods Subsequently, we investigated linezolid antibacterial activities, the first approved oxazolidinone against isolates by the standard broth microdilution method. Results: According to our results, MRSA and PNSP isolates were multidrug resistant, and almost half of the VRE isolates were high level gentamicin resistant (HLGR). Furthermore, resistance to linezolid was not seen among the isolates. The MIC90 values for MRSA, VRE, PNSP and GBS isolates were 4 mu g/ml, 2 mu g/ml, 1 mu g/ml, and 0.5 mu g/ml, respectively. Only 6.25 of vancomycin resistant enterococci showed intermediate susceptibility to this antibiotic. Conclusions: These findings indicate that linezolid has an excellent activity against clinical drug resistant Gram-positive isolates in Iran. Constant monitoring and surveillance of linezolid MIC distribution allows the researchers to assess and detect gradual upward MIC drifts. (C) 2017 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.

Item Type: Article
Creators:
CreatorsEmail
Houri, H.UNSPECIFIED
Kazemian, H.UNSPECIFIED
Ebrahim-Saraie, H. S.UNSPECIFIED
Taji, A.UNSPECIFIED
Tayebi, Z.UNSPECIFIED
Heidari, H.UNSPECIFIED
Keywords: Linezolid MRSA VRE PNSP GBS Iran streptococcus-pneumoniae enterococcus-faecalis united-states infections vancomycin mechanisms blood Infectious Diseases Pharmacology & Pharmacy
Divisions:
Page Range: pp. 200-203
Journal or Publication Title: Journal of Global Antimicrobial Resistance
Journal Index: ISI
Volume: 10
Identification Number: https://doi.org/10.1016/j.jgar.2017.06.002
ISSN: 2213-7165
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/247

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