Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

A meta-analysis of zinc levels in breast cancer

Thu Oct 6 07:28:30 2022

(2019) A meta-analysis of zinc levels in breast cancer. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). pp. 90-99. ISSN 1878-3252 (Electronic) 0946-672X (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/31442959

Abstract

BACKGROUND: Breast cancer is the most commonly occurring neoplasm in females, comprising 16 of all female cancers worldwide. Various studies indicate some discrepancies regarding zinc (Zn) levels in various samples of breast cancer patients. OBJECTIVE: The present study evaluated by meta-analysed the published data for Zn levels analyzed in breast tissue, plasma, serum, and hair samples and its relationship with breast cancer. METHODS: The present meta-analysis included 36 studies, all of which were published in the years between 1984 to 2017 and selected by searching the databases MEDLINE, EMBASE, Cochrane Library, PubMed, Scopus, and the ISI Web of Knowledge. The articles were analyzed, and I(2) statistics were used to examine heterogeneity. The objective analysis was performed on data from the 36 studies, with total 1699 study subjects and 2009 controls. RESULTS: Significant statistical differences overall were observed, based on a random effects model (SMD (95 CI), -0.78-1.40, -0.16, P=0.014). Data from 19 of these studies indicated significant statistical differences between cancerous patients and controls with regard to serum and plasma Zn concentration (SMD (95 %CI): -1.61(-2.43, -0.79). There was a significant statistical difference between the breast tissue and hair as regards Zn status (SMD (95%CI): 2.32(1.42, 3.21)) and (SMD (95v%CI): -1.80(-3.41, -0.20), respectively. Zn concentration levels typically decreased in blood and hair samples of patients with breast cancer, whereas it was elevated in tumor tissues. CONCLUSIONS: There is a significant relationship between lowered serum Zn concentrations and risk of breast cancer onset or recurrences in women, but because of high heterogeneity, we recommend other primary studies.

Item Type: Article
Creators:
CreatorsEmail
Jouybari, L.UNSPECIFIED
Kiani, F.UNSPECIFIED
Akbari, A.UNSPECIFIED
Sanagoo, A.UNSPECIFIED
Sayehmiri, F.UNSPECIFIED
Aaseth, J.UNSPECIFIED
Chartrand, M. S.UNSPECIFIED
Sayehmiri, K.UNSPECIFIED
Chirumbolo, S.UNSPECIFIED
Bjorklund, G.UNSPECIFIED
Keywords: Breast cancer Trace elements Zinc
Divisions:
Page Range: pp. 90-99
Journal or Publication Title: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
Journal Index: Pubmed
Volume: 56
Identification Number: https://doi.org/10.1016/j.jtemb.2019.06.017
ISSN: 1878-3252 (Electronic) 0946-672X (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2458

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