Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

A nanocomposite prepared from reduced graphene oxide, gold nanoparticles and poly(2-amino-5-mercapto-1,3,4-thiadiazole) for use in an electrochemical sensor for doxorubicin

Tue Dec 6 00:55:44 2022

(2019) A nanocomposite prepared from reduced graphene oxide, gold nanoparticles and poly(2-amino-5-mercapto-1,3,4-thiadiazole) for use in an electrochemical sensor for doxorubicin. Mikrochimica acta. p. 641. ISSN 1436-5073 (Electronic) 0026-3672 (Linking)

Full text not available from this repository.

Official URL: https://www.ncbi.nlm.nih.gov/pubmed/31444649

Abstract

A nanocomposite was prepared with reduced graphene oxide, gold nanoparticles and an electropolymerized film made from 2-amino-5-mercapto-1,3,4-thiadiazole. An electrochemical sensor for doxorubicin (DOX) was constructed by modifying a glassy carbon electrode (GCE) with the nanocomposite. The modified GCE was studied by electrochemical techniques which showed it to enable highly sensitive sensing of DOX. Response (typically measured at a typical working potential of -0.56 V vs. Ag/AgCl) is linear in the 30 pM to 30 nM and 30 nM to 30 muM DOX concentration ranges, with a limit of detection (LOD) of 9 pM (at an S/N ratio of 3). The method was applied to the determination of DOX in serum and gave recoveries that ranged between 92 and 108. Graphical abstract A combination of materials consisting of reduced graphene oxide (rGO), gold nanoparticles (AuNPs) and an electropolymerized film of 2-amino-5-mercapto-1,3,4-thiadiazole (poly-AMT, PAMT) is described. The nanocomposite was placed on a glassy carbon elkectrode (GCE) in order to fabricate an electrochemical sensor for doxorubicin (DOX).

Item Type: Article
Creators:
CreatorsEmail
Ghanbari, M. H.UNSPECIFIED
Shahdost-Fard, F.UNSPECIFIED
Salehzadeh, H.UNSPECIFIED
Ganjali, M. R.UNSPECIFIED
Iman, M.UNSPECIFIED
Rahimi-Nasrabadi, M.UNSPECIFIED
Ahmadi, F.UNSPECIFIED
Keywords: Doxorubicin Electrochemical sensor Gold nanoparticles Poly 2-amino-5-mercapto-1,3,4-thiadiazole Reduced graphene oxide
Divisions:
Page Range: p. 641
Journal or Publication Title: Mikrochimica acta
Journal Index: Pubmed
Volume: 186
Number: 9
Identification Number: https://doi.org/10.1007/s00604-019-3761-6
ISSN: 1436-5073 (Electronic) 0026-3672 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2457

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