Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Evidence for hyperprolactinemia in migraineurs: a systematic review and meta-analysis

Mon Nov 28 11:31:26 2022

(2019) Evidence for hyperprolactinemia in migraineurs: a systematic review and meta-analysis. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. ISSN 1590-3478 (Electronic) 1590-1874 (Linking)

Full text not available from this repository.

Official URL: https://www.ncbi.nlm.nih.gov/pubmed/31444732

Abstract

BACKGROUND: One of the hypothalamus-pituitary axis hormones which may play a crucial role in pathophysiology of migraine is prolactin which is secreted from anterior pituitary gland and synthesized by various immune system cells as well. Whether prolactin blood levels can affect the migraine pathogenesis is an open question. Therefore, investigating prolactin circulatory levels in migraineurs may pave the way to underpin the mechanisms of migraine pathophysiology at biochemical levels. In the current investigation, the prolactin blood levels in the migraine subjects were investigated using systematic review and meta-analysis. METHODS: Using online and specialized biomedical databases including Google Scholar, Medline, Pubmed, Pubmed Central, Embase, and Scopus, without the beginning date restriction until Feb 2019, the systematic review retrieved 11 publications in this systematic review after fulfilling for the inclusion and exclusion criteria. For heterogeneity, extent calculation statistical testing was applied. In the present study, the levels of circulatory prolactin in migraineurs assessed using standardized mean difference (SMD) as the effect size. RESULTS: Q quantity and I(2) statistic index showed a high heterogeneity in the 13 selected publications (188.370 and 92.568, respectively) and random-effects model was chosen for further analyses. The meta-analysis on a total number of 460 migraineurs and 429 healthy controls found that the weighted pooled SMD for the effects of prolactin blood concentrations on migraine pathogenesis was as follows: SMD = 1.435 (95 confidence interval, 0.854-2.015). CONCLUSION: The current investigation presents evidence that prolactin blood levels are higher in migraineurs than healthy subjects.

Item Type: Article
Creators:
CreatorsEmail
Noori-Zadeh, A.UNSPECIFIED
Karamkhani, M.UNSPECIFIED
Seidkhani-Nahal, A.UNSPECIFIED
Khosravi, A.UNSPECIFIED
Darabi, S.UNSPECIFIED
Keywords: Aura Migraine Pain Pituitary Prolactin
Divisions:
Journal or Publication Title: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Journal Index: Pubmed
Identification Number: https://doi.org/10.1007/s10072-019-04035-7
ISSN: 1590-3478 (Electronic) 1590-1874 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2456

Actions (login required)

View Item View Item