Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Effect of local papaverine on arteriovenous fistula maturation in patients with end-stage renal disease

Wed Nov 30 01:42:30 2022

(2019) Effect of local papaverine on arteriovenous fistula maturation in patients with end-stage renal disease. Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia. pp. 185-192. ISSN 2175-8239 (Electronic) 0101-2800 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/31498862

Abstract

BACKGROUND: Arteriovenous fistula (AVF) maturation is one of the main concerns in patients with end-stage renal disease (ESRD) and finding a strategy for increasing success rate and accelerating fistula maturation is valuable. The aim of this study was to evaluate the effects of papaverine injection on AVF maturation and success rate. METHOD: This study was a randomized clinical trial that involved 110 patients with ESRD that were referred for AVF construction. Patients were allocated in papaverine group and control group with block randomization according to age and sex. In the case group, papaverine (0.1 or 0.2 cc) was injected locally within the subadventitia of artery and vein after proximal and distal control during AVF construction and in the control group, AVF construction was done routinely without papaverine injection. RESULTS: Maturation time in case and control groups was 37.94 +/- 11.49 and 44.23 +/- 9.57 days, respectively (p=0.004). Hematoma was not seen in the case group but occurred in one patient in the control group. One patient of the case group developed venous hypertension. Four functional fistulas, 1 (1.8) in the case group and 3 (5.5) in the control group, failed to mature (p=0.618). Maturation rate did not differ between the two groups statistically (p=0.101). CONCLUSION: Local papaverine injection increased vessel diameter and blood flow, increasing shearing stress in both arterial and venous segment of recently created AVF. In this way, papaverine probably can decrease AVF maturation time without an increase in complications.

Item Type: Article
Creators:
CreatorsEmail
Manani, R.UNSPECIFIED
Kazemzadeh, G.UNSPECIFIED
Saberi, A.UNSPECIFIED
Sadeghipour, F.UNSPECIFIED
Rahmani, A.UNSPECIFIED
Divisions:
Page Range: pp. 185-192
Journal or Publication Title: Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Journal Index: Pubmed
Volume: 41
Number: 2
Identification Number: https://doi.org/10.1590/2175-8239-JBN-2018-0170
ISSN: 2175-8239 (Electronic) 0101-2800 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2453

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