Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Biochemical parameters of rickets in Iranian children: A systematic review and meta-analysis

Wed Dec 7 07:53:27 2022

(2019) Biochemical parameters of rickets in Iranian children: A systematic review and meta-analysis. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences. p. 76. ISSN 1735-1995 (Print) 1735-1995 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/31523262

Abstract

Background: Many causes can lead to childhood rickets. We aimed to investigate the biochemical symptoms of childhood rickets with systematic review and meta-analysis. Materials and Methods: Seven articles published from 1975 to 2018 were recruited. The literature search was performed in the Scientific Information Database, Google Scholar, PubMed, and Elsevier databases using related keywords. For meta-analysis, the results of the studies were pooled using the random-effects model. The heterogeneity between the studies was checked using Q test and I (2) index. Results: The total sample population consisted of 933 children with biochemical symptoms of rickets (133 participants per article). According to our findings, the mean serum levels of PO4, Ca, and alkaline phosphatase in children with rickets were 4.18 (95 confidence interval CI: 3.75-4.61, I (2) = 98.3%, P < 0.001), 9.23 (95% CI: 8.78-9.68, I (2) = 99.6%, P < 0.001), and 1.33 (95% CI: 1.23-1.44, I (2) = 95.6%, P < 0.001), respectively. Conclusion: Characterizing the biochemical symptoms of rickets in children can help to early diagnose and prevent the disease in children. Furthermore, educating parents about biochemical symptoms can lead to early diagnosis and successful treatment of rickets in children.

Item Type: Article
Creators:
CreatorsEmail
Sayehmiri, K.UNSPECIFIED
Shohani, M.UNSPECIFIED
Kalvandi, G.UNSPECIFIED
Najafi, R.UNSPECIFIED
Tavan, H.UNSPECIFIED
Keywords: Biochemical symptoms childhood meta-analysis rickets systematic review
Divisions:
Page Range: p. 76
Journal or Publication Title: Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences
Journal Index: Pubmed
Volume: 24
Identification Number: https://doi.org/10.4103/jrms.JRMS₃₅₄₁₈
ISSN: 1735-1995 (Print) 1735-1995 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2451

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