Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Comparison between the two drug regimens of PPI+Amoxicillin+ Rifampicin and PPI+Amoxicillin+ Levofloxacin for the treatment of H. pylori infections resistant to the first line drug regimen among patients referred to Ilam clinics

Wed Nov 30 17:18:22 2022

(2019) Comparison between the two drug regimens of PPI+Amoxicillin+ Rifampicin and PPI+Amoxicillin+ Levofloxacin for the treatment of H. pylori infections resistant to the first line drug regimen among patients referred to Ilam clinics. Gastroenterology and hepatology from bed to bench. pp. 209-216. ISSN 2008-2258 (Print) 2008-2258 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/31528304

Abstract

Aim: This study compares the effects of two drug regimens for Helicobacter pylori (H. pylori) infection resistant to the first line drug regimen among patients referred to Ilam clinics, Iran. Background: Single drug regimen is not effective for H. pylori infection and therefore, application of triple or quadruple drug regimens are currently applied. Methods: This study was performed by a before-after comparative method and patients were randomly selected among those consecutively referred to Ilam gastrointestinal clinics. Patients with failure in the first line treatment, were randomly divided into two equal groups and each group was treated by one of the PPI+Amoxicillin+Rifampicin or PPI+Amoxicillin+Levofloxacin drug regimens for 14 days. Six weeks after treatment, patients were tested for H. pylori stool antigen and the results were compared between two groups. Results: In this study, 100 patients including 49 (49) men and 51 (51) women were examined. There was no statistical difference between the two groups for gender, age and living location at the start of study (p = 0.068). The mean age of the patients was 44.55 +/-15.1 years old ranging from 17 to 85 years. Response to treatment among the levofloxacin group, was 90 and in rifampicin group 72 with a significant difference (p<0.04). Conclusion: The response rate of H. pylori infection to the Levofloxacin based regimen was 90; however, the application of rifampicin in combination with other drugs against H. pylori infection (72 response rate), should be limited to reduce the possibility of drug resistance in case of tuberculosis infection.

Item Type: Article
Creators:
CreatorsEmail
Abangah, G.UNSPECIFIED
Raughani, A.UNSPECIFIED
Asadollahi, P.UNSPECIFIED
Asadollahi, K.UNSPECIFIED
Keywords: Drug resistance Helicobacter pylori Levofloxacin Ppi Rifampicin
Divisions:
Page Range: pp. 209-216
Journal or Publication Title: Gastroenterology and hepatology from bed to bench
Journal Index: Pubmed
Volume: 12
Number: 3
ISSN: 2008-2258 (Print) 2008-2258 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2450

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