Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Anti-Atherosclerotic Effects of the Hydroalcoholic Extract of Crocus sativus L. (saffron) Petals on Hypercholesterolemic Rats

Mon Jun 27 09:55:45 2022

(2018) Anti-Atherosclerotic Effects of the Hydroalcoholic Extract of Crocus sativus L. (saffron) Petals on Hypercholesterolemic Rats. International Journal of Pharmaceutical and Phytopharmacological Research. pp. 99-104. ISSN 2250-1029

Full text not available from this repository.

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

Cardiovascular diseases are the major causes of mortalities worldwide. One of the methods for preventing and fighting cardiovascular diseases is the use of medicinal herbs that have been known to have fewer side effects as compared to chemical drugs. The present study aimed at investigating the effects of the hydroalcoholic extract of saffron (Crocus Sativus L.) petals on the atherosclerotic plaques. For this purpose, male Wistar Rats with the average weights of 170-220 g were assigned to six 5-member groups. The treatments lasted for 6 weeks. To perform histological examinations, the aorta and hearts of the rats were dissected at the end of the 6th week, and kept in a 10 formalin solution. The aorta tissues in the control group were fed with an ordinary diet and were thus completely healthy and natural, but atherogenic lesions and plaque formation symptoms were evidenced in the sham group that had been fed with a high-cholesterol diet. No signs of tissue or atherogenic lesions were detected in the 4 experimental groups treated with saffron petal extract plus lovastatin at various dosages. Also, a significant difference was found between the average weights of all the groups and the sham group (P<0.001). The hydroalcoholic extract of saffron petals was interestingly found to act like lovastatin, which is a chemical drug for preventing atherogenic lesions. Compared to chemical drugs, medicinal herbs as a source of different antioxidants can provide an appropriate alternative mitigation of cardiovascular diseases.

Item Type: Article
Creators:
CreatorsEmail
Ghorbani, A.UNSPECIFIED
Shirzadpour, E.UNSPECIFIED
Kaffashian, M. R.UNSPECIFIED
Mohamadpour, S.UNSPECIFIED
Seifinejad, Y.UNSPECIFIED
Amraei, M.UNSPECIFIED
Keywords: Cardiovascular diseases Crocus Sativus L. Hydroalcoholic extract Atherosclerotic plaques Rats radical scavenging activity atherosclerosis constituents flavonoids capacities cinnamon crocetin stigma Pharmacology & Pharmacy
Divisions:
Page Range: pp. 99-104
Journal or Publication Title: International Journal of Pharmaceutical and Phytopharmacological Research
Journal Index: ISI
Volume: 8
Number: 6
ISSN: 2250-1029
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2445

Actions (login required)

View Item View Item