Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The Relationship Between Prostate Cancer and Metformin Consumption: A Systematic Review and Meta-analysis Study

Sat Oct 1 18:45:41 2022

(2019) The Relationship Between Prostate Cancer and Metformin Consumption: A Systematic Review and Meta-analysis Study. Current Pharmaceutical Design. pp. 1021-1029. ISSN 1381-6128

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Abstract

Introduction: Prostate cancer is the most common malignant cancer in men worldwide and after lung cancer, it is the second leading cause of cancer mortality in men. The purpose of this study was to investigate the relationship between prostate cancer and metformin consumption in men. Methods: The current study is a systematic and meta-analysis review based on the PRISMA statement. To access the studies of domestic and foreign databases, Iran Medex, SID, Magiran, Iran Doc, Medlib, ProQuest, Science Direct, PubMed, Scopus, Web of Science and the Google Scholar search engine were searched during the 2009-2018 period for related keywords. In order to evaluate the heterogeneity of the studies, Q test and I-2 indicator were used. The data were analyzed using the STATA 15.1 software. Results: In 11 studies with a sample size of 877058, the odds ratio of metformin consumption for reducing prostate cancer was estimated at 0.89 (95CI: 0.67-1.17). Meta-regression also showed there was no significant relationship between the odds ratio and the publication year of the study. However, there was a significant relationship between the odds ratio and the number of research samples. Conclusion: Using metformin in men reduces the risk of prostate cancer but it is not statistically significant.

Item Type: Article
Creators:
CreatorsEmail
Ghiasi, B.UNSPECIFIED
Sarokhani, D.UNSPECIFIED
Najafi, F.UNSPECIFIED
Motedayen, M.UNSPECIFIED
Dehkordi, A. H.UNSPECIFIED
Keywords: Metformin prostate cancer chronic diseases I-2 indicator lung cancer Q test quality-of-life incident cancer reduced risk mortality association biguanides therapy growth trial Pharmacology & Pharmacy
Divisions:
Page Range: pp. 1021-1029
Journal or Publication Title: Current Pharmaceutical Design
Journal Index: ISI
Volume: 25
Number: 9
Identification Number: https://doi.org/10.2174/1381612825666190215123759
ISSN: 1381-6128
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2428

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