Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Synthesis and Evaluation of the Antibacterial Effect of Titanium Dioxide Nanoparticles in Comparison with Ampicillin, Colistin, and Ertapenem on Staphylococcus aureus

Thu May 23 03:03:09 2024

(2019) Synthesis and Evaluation of the Antibacterial Effect of Titanium Dioxide Nanoparticles in Comparison with Ampicillin, Colistin, and Ertapenem on Staphylococcus aureus. Journal of Pharmaceutical Negative Results. pp. 16-20. ISSN 0976-9234

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Objectives: Today, the emergence of antibiotic-resistant strains and the acquisition of antibiotic resistance have caused many problems in the treatment of Staphylococcus aureus infection and is one of the most important health issues. At present, nanotechnology has a significant impact on the various fields including pharmacology, health, medicine, and food. This study aimed to synthesize the titanium dioxide nanoparticles (Tio(2)NPs) and its antibacterial effect on S. aureus compared with conventional antibiotics. Materials and Methods: In this study, Tio(2)NPs were tested on S. aureus compared with a number of antibiotics. First, Tio(2)NPs were synthesized. The shape and size of the particles as well as the synthesis quality were investigated using scanning electron microscopy (SEM), atomic force microscopy (AFM), dynamic light scattering, zeta potential and X-ray diffraction, and Fourier-transform infrared spectroscopy. The antimicrobial effect of Tio(2)NPs on S. aureus strain (ATCC 12600) was then studied by disc diffusion method. Antibiotics of ampicillin, colistin, and ertapenem were used as control group. Results: Based on the results and given that the polydispersity index of the samples was below 0.5 (0.466), the other sample was estimated at 347.9 nm. The zeta potential of Tio(2) sample was estimated at -9.48 indicating the stability of the nanoparticle and its suspension in a suitable amount per unit of time in the solution. The results of the AFM showed that the lower mean value obtained for the Tio(2)NPs was 0.5 nm, and the growth of the nanoparticles was noticeable in some regions and uniform and low in some others. The result of SEM showed that the size of the nanoparticle was 28.45-34.14 nm. The best inhibition zone diameter was obtained for ampicillin (30.66 mm), followed by ertapenem (15 mm) and Tio(2)(10 mm). Colistin without inhibition zone was identified as ineffective group. Conclusion: Due to the development of drug resistance to antibiotics, the production and synthesis of antimicrobial agents is one of the requirements of the current time. Due to the excellent synthesis of Tio(2) and the presence of very fine nanoparticles, it can be used as a strong antimicrobial compound, especially on S. aureus infection.

Item Type: Article
Taherikalani, M.UNSPECIFIED
Rafieian-Kopaei, M.UNSPECIFIED
Keywords: Antibiotic disease infection nanoparticle Staphylococcus aureus titanium dioxide clinical-manifestations silver nanoparticles cytotoxicity epidemiology mechanisms cells Pharmacology & Pharmacy
Page Range: pp. 16-20
Journal or Publication Title: Journal of Pharmaceutical Negative Results
Journal Index: ISI
Volume: 10
Number: 1
Identification Number:₂₁₁₈
ISSN: 0976-9234
Depositing User: مهندس مهدی شریفی

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