Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Is mannose-binding lectin serum concentration a reliable predictor for recurrent vulvovaginal candidiasis?

Thu Dec 1 17:48:54 2022

(2019) Is mannose-binding lectin serum concentration a reliable predictor for recurrent vulvovaginal candidiasis? Mycoses. pp. 106-111. ISSN 0933-7407

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Abstract

Recurrent vulvovaginal candidiasis (RVVC) is a common opportunistic, mucosal fungal infection, predominantly caused by the fungus Candida albicans. Mannose-binding lectin (MBL) is an acute-phase protein that plays a key role in the innate immunity defence against infectious disease. This study was conducted to evaluate the relationship between the MBL serum level and the relative expression of MBL mRNA in RVVC using real-time PCR for the first time. The case-control study included 40 female participants suffering from RVVC and 40 healthy individuals. The MBL serum level was measured using a commercial ELISA kit. The relative mRNA expression of the MBL gene was quantified using real-time PCR. Data analysis was carried out by spss software. The MBL concentration was significantly higher in the participants suffering from RVVC compared to the control group (0.330 ng/mL vs 0.253 ng/mL). The prognostic value (P < .001) for RVVC diagnosis has been calculated. Quantitative RT-PCR results from 35 samples showed a low to significant values for mRNA levels corresponding to MBL gene expression (1-352 folds) (P < .001). The results of this study suggest that MBL plays a main role in the innate immunity and it is also affected by environmental factors and other genetic variations. Therefore, the MBL gene expression profile does not reflect precise phenotypic levels in the serum.

Item Type: Article
Creators:
CreatorsEmail
Ghazanfari, M.UNSPECIFIED
Falahati, M.UNSPECIFIED
Fattahi, A.UNSPECIFIED
Bazrafshan, F.UNSPECIFIED
Nami, S.UNSPECIFIED
Hosseinzadeh, M.UNSPECIFIED
Heydarikohan, F.UNSPECIFIED
Ghelman, M.UNSPECIFIED
Khoshmirsafa, M.UNSPECIFIED
Farzanegan, A.UNSPECIFIED
Keywords: gene expression mannose-binding lectin recurrent vulvovaginal candidiasis gene polymorphism infection albicans therapy level Dermatology Mycology
Divisions:
Page Range: pp. 106-111
Journal or Publication Title: Mycoses
Journal Index: ISI
Volume: 62
Number: 2
Identification Number: https://doi.org/10.1111/myc.12723
ISSN: 0933-7407
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2422

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