Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

A nanocomposite consisting of reduced graphene oxide and electropolymerized -cyclodextrin for voltammetric sensing of levofloxacin

Sat Oct 1 18:59:11 2022

(2019) A nanocomposite consisting of reduced graphene oxide and electropolymerized -cyclodextrin for voltammetric sensing of levofloxacin. Microchimica Acta. p. 11. ISSN 0026-3672

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Abstract

A glassy carbon electrode (GCE) was modified with a nanocomposite prepared from polymerized -cyclodextrin (-CD) and reduced graphene oxide (rGO). The modified GCE is shown to enable the voltammetric determination of traces of levofloxacin (LEV) by various electrochemical techniques. Experimental factors affecting the results including the amount of the substrates in preparation of the nanocomposite, accumulation time, the scan rate and pH value of the electrolyte were optimized. The modified GCE, best operated at a working potential of 1.00V (vs. Ag/AgCl), has two linear response ranges, one for low LEV concentrations (100pmolL(-1) to 100nmolL(-1)), and one for higher LEV concentrations (100nmolL(-1) to 100molL(-1)). The limit of detection and sensitivity are calculated to be 30pmolL(-1) and 467.33nAmolL(-1)cm(-2), respectively. The modified GCE demonstrates a number of advantages such as high sensitivity and selectivity, low LOD, excellent reproducibility, high surface-to-volume ratio, and good electrocatalytic activity towards LEV. The sensor was successfully applied to the determination of LEV in spiked human serum samples.

Item Type: Article
Creators:
CreatorsEmail
Ghanbari, M. H.UNSPECIFIED
Shahdost-fard, F.UNSPECIFIED
Khoshroo, A.UNSPECIFIED
Rahimi-Nasrabadi, M.UNSPECIFIED
Ganjali, M. R.UNSPECIFIED
Wysokowski, M.UNSPECIFIED
Rebis, T.UNSPECIFIED
Zoltowska-Aksamitowska, S.UNSPECIFIED
Jesionowski, T.UNSPECIFIED
Rahimi, P.UNSPECIFIED
Joseph, Y.UNSPECIFIED
Ehrlich, H.UNSPECIFIED
Keywords: Antibacterial agent Electropolymerization Nanocomposite Electrochemical sensing screen-printed electrode glassy-carbon electrode electrochemical sensor sensitive determination selective detection gold nanoparticles beta-cyclodextrin composite film ascorbic-acid dopamine Chemistry
Divisions:
Page Range: p. 11
Journal or Publication Title: Microchimica Acta
Journal Index: ISI
Volume: 186
Number: 7
Identification Number: https://doi.org/10.1007/s00604-019-3530-6
ISSN: 0026-3672
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2379

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