Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Synthesis of a copolymer carrier for anticancer drug luteolin for targeting human breast cancer cells

Sat Oct 1 17:50:58 2022

(2019) Synthesis of a copolymer carrier for anticancer drug luteolin for targeting human breast cancer cells. Journal of Traditional Chinese Medicine. pp. 474-481. ISSN 0255-2922

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Abstract

OBJECTIVE: To focus a new chemoprevention approach that uses nanotechnology to deliver luteolin to human breast cancer cells (MCF-7), and its underlying mechanism. METHODS: Water-soluble copolymer-encapsulated nanoparticle-luteolin (CENL) was formulated using the hydrophobic drug luteolin. The ability to load and release he anticancer drug into/from the synthesized hyperbranched polyester was evaluated by high-performance liquid chromatography. The successful synthesis of CENL was supported by analytical techniques including fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, gel permeation chromatography, and dynamic light scattering. Cell viability was measured using the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide color method. Reactive oxygen species (ROS) were measured using a dichlorofluorescein probe and intracellular calcium (Cai(2+)) was evaluated with a flu3-AM probe. RESULTS: The results showed that the drug delivery system is stable and that the loading capacity is high. Treatment with nanoparticles containing luteolin and free luteolin resulted in cell death in breast cancer cells at high concentrations IC50 (33 +/- 4) and (48 +/- 6) M, respectively. At high concentrations, CENL reduced cell viability and increased ROS and Cai' production. CONCLUSION: Our results demonstrate that CENL has potential for human breast cancer treatment. (C) 2019 JTCM. All rights reserved.

Item Type: Article
Creators:
CreatorsEmail
Maleki, M.UNSPECIFIED
Aidy, A.UNSPECIFIED
Karimi, E.UNSPECIFIED
Shahbazi, S.UNSPECIFIED
Safarian, N.UNSPECIFIED
Abbasi, N.UNSPECIFIED
Keywords: Polymers Materials testing Drug delivery systems Luteolin aqueous-solution delivery proliferation inhibition efficacy platform Integrative & Complementary Medicine
Divisions:
Page Range: pp. 474-481
Journal or Publication Title: Journal of Traditional Chinese Medicine
Journal Index: ISI
Volume: 39
Number: 4
ISSN: 0255-2922
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2361

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