Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The relation of maternal hypothyroidism and hypothyroxinemia during pregnancy on preterm birth: An updated systematic review and meta-analysis

Thu Aug 11 17:15:40 2022

(2017) The relation of maternal hypothyroidism and hypothyroxinemia during pregnancy on preterm birth: An updated systematic review and meta-analysis. International Journal of Reproductive Biomedicine. pp. 543-552. ISSN 2476-4108

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Abstract

Background: The clinical consequences of hypothyroidism and hypothyroxinemia during pregnancy such as preterm birth are not still clear. Objective: The aim of this meta-analysis was to estimate the relation of clinical and subclinical hypothyroidism and hypothyroxinemia during pregnancy and preterm birth. Materials and Methods: In this meta-analysis, Preferred Reporting Items for Systematic review and Meta-Analysis were utilized. Searching the cohort studies were done by two researchers independently without any restrictions on Scopus, PubMed, Science Direct, Embase, Web of Science, CINAHL, Cochrane, EBSCO and Google Scholar databases up to 2017. The heterogeneity of the studies was checked by the Cochran's Q test and I-2 index. Both random and fixed-effects models were used for combining the relative risk and 95 confidence intervals. Data were analyzed using Comprehensive Meta-Analysis software version 2. Results: Twenty-three studies were included in the meta-analysis. The relative risks of the clinical hypothyroidism, subclinical hypothyroidism and hypothyroxinemia during pregnancy on preterm birth was estimated 1.30 (95 CI: 1.05-1.61, p=0.013, involving 20079 cases and 2452817 controls), 1.36 (95 CI: 1.09-1.68, p=0.005, involving 3580 cases and 64885 controls) and 1.31 (95 CI: 1.04-1.66, p=0.020, involving 1078 cases and 44377 controls), respectively. Conclusion: The incidence of preterm birth was higher among mothers with clinical and subclinical hypothyroidism or hypothyroxinemia during pregnancy compared to euthyroid mothers, and these relations were significant. Therefore, gynecologists and endocrinologists should manage these patients to control the incidence of adverse pregnancy outcomes such as preterm birth.

Item Type: Article
Creators:
CreatorsEmail
Nasirkandy, M. P.UNSPECIFIED
Badfar, G.UNSPECIFIED
Shohani, M.UNSPECIFIED
Rahmati, S.UNSPECIFIED
YektaKooshali, M. H.UNSPECIFIED
Abbasalizadeh, S.UNSPECIFIED
Soleymani, A.UNSPECIFIED
Azami, M.UNSPECIFIED
Keywords: Hypothyroidism Pregnancy Preterm birth Meta-analysis Cohort population-based cohort thyroid-dysfunction subclinical hypothyroidism outcomes risk disease women infection gestation delivery Obstetrics & Gynecology
Divisions:
Page Range: pp. 543-552
Journal or Publication Title: International Journal of Reproductive Biomedicine
Journal Index: ISI
Volume: 15
Number: 9
ISSN: 2476-4108
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/236

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