Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The therapeutic effect of platelet-rich plasma on the experimental autoimmune encephalomyelitis mice

Tue Jul 23 03:35:39 2024

(2019) The therapeutic effect of platelet-rich plasma on the experimental autoimmune encephalomyelitis mice. Journal of Neuroimmunology. p. 7. ISSN 0165-5728

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The use of growth factors is considered to be one of the promising therapeutic strategies for multiple sclerosis (MS). Various studies have shown that platelet-rich plasma (PRP), a bioproduct of concentrated platelets, contains a variety of growth factors such as insulin-like growth factor 1 (IGF-1), platelet-derived growth factor (PDGF), epithelial growth factor (EGF), and transforming growth factor beta (TGF-beta). The therapeutic roles of PRP, with regard to a wide range of growth factors, on the nervous system have been shown in a limited number of studies. This study aimed to investigate the therapeutic effect of PRP in experimental autoimmune encephalomyelitis (EAE) mouse model of MS. PRP was prepared and intrathecally injected into the EAE mice. The EAE scoring test, the modified neurological severity score (mNSS) test, luxol fast blue and hematoxylin and eosin staining, real-time PCR, and western blotting were used for studying the effect of PRP on the motosensory function, remyelination, inflammatory cell infiltration, gliosis, and inflammatory cytokines expression. PRP administration in treated animals improved the functional abilities, remyelination, and oligodendrogenesis compared to the EAE mice. Furthermore, high numbers of microglia, astrocytes and infiltrating inflammatory cells and also the expression of proinflammatory cytokines were reversed after PRP therapy. In conclusion, these data suggest the PRP as a potential candidate for MS treatment.

Item Type: Article
Borhani-Haghighi, M.UNSPECIFIED
Keywords: Platelet-rich plasma Multiple sclerosis Experimental autoimmune encephalomyelitis Growth factor Inflammation Myelination growth-factor-i mesenchymal stem-cells injury myelin remyelination demyelination injections proteins Immunology Neurosciences & Neurology
Page Range: p. 7
Journal or Publication Title: Journal of Neuroimmunology
Journal Index: ISI
Volume: 333
Identification Number:
ISSN: 0165-5728
Depositing User: مهندس مهدی شریفی

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