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Repository of Research and Investigative Information

Ilam University of Medical Sciences

Synthesis of titanium nanoparticles using Allium eriophyllum Boiss aqueous extract by green synthesis method and evaluation of their remedial properties

Sat Oct 1 09:20:04 2022

(2019) Synthesis of titanium nanoparticles using Allium eriophyllum Boiss aqueous extract by green synthesis method and evaluation of their remedial properties. Applied Organometallic Chemistry. p. 18. ISSN 0268-2605

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Abstract

The application of nanotechnologies to medicine, or nanomedicine, which has already demonstrated its tremendous impact on the pharmaceutical and biotechnology industries, is rapidly becoming a major driving force behind ongoing developments in the antimicrobial and wound healing fields. This study confirms the potential of Allium eriophyllum Boiss aqueous extract for the green synthesis of titanium nanoparticles (TiNPs). Also, we reveal the antioxidant, cytotoxicity, cutaneous wound healing, antifungal and antibacterial properties of TiNPs. These nanoparticles were characterized using Fourier transform infrared (FT-IR) and UV-visible spectroscopies, X-ray diffraction (XRD), transmission electron microscopy (TEM) and field emission scanning electron microscopy (SEM). FT-IR findings suggested molecular interactions of compounds in the plant were the sources of reducing power, reducing titanium ions to TiNPs. In XRD analysis, 22.8 nm was measured for the crystal size of the nanoparticles. SEM and TEM images indicated a uniform spherical morphology and average diameters of 22 nm. 2,2-Diphenyl-1-picrylhydrazyl experiments were conducted to assess the antioxidant activities, which indicated similar antioxidant potentials for TiNPs and butylated hydroxytoluene. In the antimicrobial part of this study, agar diffusion experiments were done to determine the antibacterial and antifungal characteristics. TiNPs had antifungal activities against Candida guilliermondii, C. krusei, C. albicans and C. glabrata and antibacterial potentials against Gram-negative bacteria (Pseudomonas aeruginosa, Salmonella typhimurium and Escherichia coli O157:H7) and Gram-positive bacteria (Staphylococcus aureus, Streptococcus pneumoniae and Bacillus subtilis). Also, these nanoparticles did not have any cytotoxicity against human umbilical vein endothelial cells. In in vivo experiments, TiNP ointment significantly decreased (p <= 0.01) wound area, total cells, macrophages, neutrophils and lymphocytes and notably increased (p <= 0.01) wound contracture, vessels, hydroxyproline, hexosamine, hexuronic acid, fibrocytes and fibrocyte/fibroblast ratio in rats. The results of FT-IR, UV, XRD, TEM and SEM analyses confirm that aqueous extract of A. eriophyllum leaves can be used to yield TiNPs with notable antioxidant, antibacterial, antifungal and cutaneous wound healing potentials without any cytotoxicity. Further clinical trials are necessary for confirmation of these remedial properties of TiNPs in humans.

Item Type: Article
Creators:
CreatorsEmail
Seydi, N.UNSPECIFIED
Saneei, S.UNSPECIFIED
Jalalvand, A. R.UNSPECIFIED
Zangeneh, M. M.UNSPECIFIED
Zangeneh, A.UNSPECIFIED
Tahvilian, R.UNSPECIFIED
Pirabbasi, E.UNSPECIFIED
Keywords: Allium eriophyllum Boiss antimicrobial antioxidant cutaneous wound healing titanium nanoparticles chitosan nanoparticles mediated biosynthesis gold nanoparticles skin wounds antibacterial silver antioxidant capabilities mechanism acid Chemistry
Divisions:
Page Range: p. 18
Journal or Publication Title: Applied Organometallic Chemistry
Journal Index: ISI
Identification Number: https://doi.org/10.1002/aoc.5191
ISSN: 0268-2605
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2355

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