Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Advantages and Disadvantages of Methadone among Children and Adults: A Systematic Review and Meta-Analysis

Sun Oct 2 22:28:01 2022

(2019) Advantages and Disadvantages of Methadone among Children and Adults: A Systematic Review and Meta-Analysis. International Journal of Pediatrics-Mashhad. pp. 10125-10139. ISSN 2345-5047

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Abstract

Background: Today, an increasing trend to methadone as an alternative maintenance treatment for opiate dependence in adults is observed; children for both intentional and accidental reasons are exposed to serious and fetal effects of methadone. We aimed to investigate effects of methadone on children and sexual functioning among adults in Iranian population. Materials and Methods: An extensive search was done in databases of Medline, EMBASE, Scopus, Cochrane, and Web of Science until August 2018. Two independent researchers screened articles, and categorized them based on the evaluated outcomes and overall effect size was presented. After excluding the duplicated, irrelevant and low-quality articles, eligible ones were enrolled in the meta-analysis. Finally, pooled effect size was presented as standardized mean difference (SMD) or pooled prevalence with 95 confidence interval (95 CI). Results: Methadone was found to be more effective than morphine on neonatal abstinence syndrome. The first four most common symptoms of methadone poisoning were loss of consciousness (81), sleepiness (72), meiotic pupils (76), vomiting (56), and Apnea (48). The overall prevalence rate of sexual disorders and erectile dysfunction was 66.3 and 77.5, respectively. The subjects in methadone group were over 2.5-fold more likely to use condom during intercourse (p<0.001). The methadone therapy could lead to a significant reduction in orgasm functioning (p<0.001), and a significant improvement in libido (p=0.001). The methadone maintenance treatment (MMT) significantly resulted in decreased orgasm function and improved libido in males. Conclusion: Evidence suggests a positive impact of methadone maintenance treatment on risky sexual behaviors. Regarding the methadone poisoning effect on children, people should be informed by health care providers about serious and fetal effects on children.

Item Type: Article
Creators:
CreatorsEmail
Babakhanian, M.UNSPECIFIED
Kani, K. M.UNSPECIFIED
Shojaei, H.UNSPECIFIED
Nezhad, R. M.UNSPECIFIED
Daneshvar, F.UNSPECIFIED
Sayehmire, K.UNSPECIFIED
Khosravifar, S.UNSPECIFIED
Khosravifar, S.UNSPECIFIED
Fattah, A.UNSPECIFIED
Ghazanfarpour, M.UNSPECIFIED
Mirzaee, F.UNSPECIFIED
Keywords: Children Iran Methadone Meta-Analysis Poisoning Sexual functioning risk behaviors methodological quality sexual dysfunction measurement tool drug-use hiv buprenorphine amstar Pediatrics
Divisions:
Page Range: pp. 10125-10139
Journal or Publication Title: International Journal of Pediatrics-Mashhad
Journal Index: ISI
Volume: 7
Number: 9
Identification Number: https://doi.org/10.22038/ijp.2019.41697.3511
ISSN: 2345-5047
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2352

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