Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Antiulcer activity of aqueous extract of leaves of Mentha piperita in Wistar rats

Wed Jul 24 15:21:01 2024

(2019) Antiulcer activity of aqueous extract of leaves of Mentha piperita in Wistar rats. Comparative Clinical Pathology. pp. 411-418. ISSN 16185641 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Because many people in the world suffer from gastroduodenal ulcers, therefore, studying the therapeutic strategies of these ulcers are research priorities in any country. The aim of the new study was to survey the preventive property of aqueous extract of Mentha piperita on ethanol-induced gastroduodenal ulcers in rats. In this study, 60 rats were used. The rodents were randomly divided into six subgroups, including negative healthy control receiving distilled water, untreated negative control receiving distilled water, positive control receiving omeprazole 60 mg/kg, and three groups receiving the aqueous extract of M. piperita at 20, 60, and 180 mg/kg concentrations. After 14 days, gastroduodenal ulcers were caused by ethanol. Four hours after oral administration of ethanol, the rats were dissected and blood, stomach, and duodenum samples of them collected for hematological, biochemical, and gross parameter analysis. The data were analyzed using one-way ANOVA followed by Duncan post hoc test. Different doses of M. piperita could significantly (p ≤ 0.05) decrease the raised levels of ALP, AST, ALT, GGT, cholesterol, LDL, triglyceride, total and conjugated bilirubin, urea, and creatinine, and enhance HDL, total protein, albumin, WBC, platelet, RBC, Hb, PCV, MCV, MCH, and MCHC as compared to the untreated group. Also, the extract prevented significantly (p ≤ 0.05) small, medium, and large gastroduodenal ulcers as compared to the untreated group. In conclusion, it seems that the aqueous extract of M. piperita can prevent gastroduodenal ulcers in rats without any side effect. © 2018, Springer-Verlag London Ltd., part of Springer Nature.

Item Type: Article
Creators:
CreatorsEmail
Zangeneh, M. M.UNSPECIFIED
Salmani, S.UNSPECIFIED
Zangeneh, A.UNSPECIFIED
Bahrami, E.UNSPECIFIED
Almasi, M.UNSPECIFIED
Keywords: Ethanol Gastroduodenal ulcers protective Mentha piperita Rats
Divisions:
Page Range: pp. 411-418
Journal or Publication Title: Comparative Clinical Pathology
Journal Index: Scopus
Volume: 28
Number: 2
Identification Number: https://doi.org/10.1007/s00580-018-2827-x
ISSN: 16185641 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2323

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