Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Immune system and new avenues in Parkinson's disease research and treatment

Sat Dec 10 01:26:20 2022

(2019) Immune system and new avenues in Parkinson's disease research and treatment. Reviews in the neurosciences. ISSN 0334-1763 (Print) 0334-1763 (Linking)

Full text not available from this repository.

Official URL: https://www.ncbi.nlm.nih.gov/pubmed/30796849

Abstract

Parkinson's disease (PD) is a progressive neurological disorder characterized by degeneration of dopaminergic neurons in the substantia nigra. However, although 200 years have now passed since the primary clinical description of PD by James Parkinson, the etiology and mechanisms of neuronal loss in this disease are still not fully understood. In addition to genetic and environmental factors, activation of immunologic responses seems to have a crucial role in PD pathology. Intraneuronal accumulation of alpha-synuclein (alpha-Syn), as the main pathological hallmark of PD, potentially mediates initiation of the autoimmune and inflammatory events through, possibly, auto-reactive T cells. While current therapeutic regimens are mainly used to symptomatically suppress PD signs, application of the disease-modifying therapies including immunomodulatory strategies may slow down the progressive neurodegeneration process of PD. The aim of this review is to summarize knowledge regarding previous studies on the relationships between autoimmune reactions and PD pathology as well as to discuss current opportunities for immunomodulatory therapy.

Item Type: Article
Creators:
CreatorsEmail
Nasrolahi, A.UNSPECIFIED
Safari, F.UNSPECIFIED
Farhoudi, M.UNSPECIFIED
Khosravi, A.UNSPECIFIED
Farajdokht, F.UNSPECIFIED
Bastaminejad, S.UNSPECIFIED
Sandoghchian Shotorbani, S.UNSPECIFIED
Mahmoudi, J.UNSPECIFIED
Keywords: T cell autoantibody human leukocyte antigen immunotherapy microglia activation neuroinflammation
Divisions:
Journal or Publication Title: Reviews in the neurosciences
Journal Index: Pubmed
Identification Number: https://doi.org/10.1515/revneuro-2018-0105
ISSN: 0334-1763 (Print) 0334-1763 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/2309

Actions (login required)

View Item View Item