Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

SURVEY THE MUTATION OF FGB (BETA FIBRINOGEN) AND FV (FACTOR V LEIDEN), FACTOR XIII AND FACTOR II (PROTHROMBIN), IN PATIENTS WITH RECURRENT ABORTIONS ALONG WITH NORMAL KARYOTYPE

Wed Jul 24 10:17:41 2024

(2017) SURVEY THE MUTATION OF FGB (BETA FIBRINOGEN) AND FV (FACTOR V LEIDEN), FACTOR XIII AND FACTOR II (PROTHROMBIN), IN PATIENTS WITH RECURRENT ABORTIONS ALONG WITH NORMAL KARYOTYPE. Indo American Journal of Pharmaceutical Sciences. pp. 3458-3463. ISSN 2349-7750

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Abstract

Some pregnancies are abnormal in human genetically and end with the spontaneous abortion, which is the most common problem of pregnancy. The recurrent abortions are often referred to as multifactorial disease that one of which is thrombosis. The thrombosis in placenta capillaries seems to disturb the blood circulation between the mother and the fetus and eventually lead to abortion. Recently, studies have shown that genetic basis for thrombophilia relates with recurrent abortion. The aim of this study is the survey of G1691A and G4070A mutations in the Factor V gene, -455G>A mutation in the gen of XIII factor, G103T mutation in Beta fibrinogen and A20210G mutation in the thrombin gene. The samples were collected from 60 patients referred to Tehran Imam Khomeini hospital .DNA was extracted from patients' blood samples by multiple PCR simultaneously containing different mutations were duplicated then the existence of mutation was evaluated by the strip technique. The genes mutation of G1691A in Factor V, G4070A in Factor V, G103T in Beta fibrinogen, -455G>A in the XIII factor and G20210A were identified 6.6, 45, 36, 40 and 3.3 respectively. Studies on the other population showed that frequency of examined mutations varies with other communities. Anyway, more samples are required in order to obtain more accurate statistics related to the frequency of mutations.

Item Type: Article
Creators:
CreatorsEmail
Moghadam, M. H.UNSPECIFIED
Larki, P.UNSPECIFIED
Panahi, J.UNSPECIFIED
Mojtahedifard, N.UNSPECIFIED
Shakoori, A.UNSPECIFIED
Keywords: Factor V Factor XIII fibrinogen prothrombin spontaneous abortion thrombosis thrombophilia strip technique natural-killer-cells pregnancy loss miscarriage risk population g20210a prevalence prognosis gene Pharmacology & Pharmacy
Divisions:
Page Range: pp. 3458-3463
Journal or Publication Title: Indo American Journal of Pharmaceutical Sciences
Journal Index: ISI
Volume: 4
Number: 10
Identification Number: https://doi.org/10.5281/zenodo.1001734
ISSN: 2349-7750
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/220

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