Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The Analgesic and Anti-Inflammatory Activity of Linum usitatissimum in Balb/c Mice

Tue Jul 23 08:56:59 2024

(2017) The Analgesic and Anti-Inflammatory Activity of Linum usitatissimum in Balb/c Mice. Journal of Evidence-Based Integrative Medicine. pp. 892-896. ISSN 2515-690X

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Linum usitatissimum L is traditionally used for relief of pain and inflammation. In this study, the analgesic and anti-inflammatory effects of this plant were evaluated. Xylene test was used for anti-inflammatory evaluation in which 48 mice were randomly designated into 6 groups of 8 each including: control, dexamethasone as positive control (15 mg/kg), and experimental groups (42, 85, 170, and 340 mg/kg, respectively). For analgesic evaluation, 192 mice were randomly designated into 4 sets of 6 groups of 8 mice, including control, morphine as positive control, morphine plus naloxone, experimental groups (200 and 500 mg/kg extract), and extract along with naloxone group, which received 500 mg/kg. The analgesic activities were evaluated at 5, 15, 30, and 60 minutes, respectively, in each set. Both doses showed analgesic activity, the 200 mg/kg possessed higher effects (P <.05). Naloxone reduced a section of its effect (P <.001). The 170 mg/kg dose of the extract showed anti-inflammatory activity (P <.05). The extract had phenolic, flavonoid, and flavonol compounds with antioxidant activity. Linum usitatissimum L dose dependently had analgesic activity partially like morphine and might be used as analgesic and anti-inflammatory agent.

Item Type: Article
Rafieian-Kopaei, M.UNSPECIFIED
Keywords: Linum usitatissimum L pain inflammation mice chemical-composition essential oil extract rhizome rats Integrative & Complementary Medicine
Page Range: pp. 892-896
Journal or Publication Title: Journal of Evidence-Based Integrative Medicine
Journal Index: ISI
Volume: 22
Number: 4
Identification Number:
ISSN: 2515-690X
Depositing User: مهندس مهدی شریفی

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