Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Renin-angiotensin system and unilateral ureteral obstruction

Mon Jun 17 01:01:31 2024

(2017) Renin-angiotensin system and unilateral ureteral obstruction. Physiology and Pharmacology. pp. 266-278. ISSN 2476-5236

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Unilateral ureteral obstruction (UUO) is a clinical scenario that leads to obstructive nephropathy. UUO alters the expression of many mediators in the ipsilateral kidney. Renin-angiotensin system (RAS) is involved in UUO. Angiotensin II (Ang II) and angiotensin 1-7 (Ang 1-7) as the main arms of RAS influence kidney function which may alter by UUO. Ang II via Ang II receptor subtypes I (AT(1)R) reduces renal blood flow and glomerular filtration rate and induces oxidative stress, apoptosis as well as inflammation in renal tissue and contributes to renal fibrosis in UUO model. Also, Ang 1-7 receptor (MasR) and Ang II receptor subtype II (AT(2)R) may have a protective effect against UUO-induced renal injury. In addition, there is crosstalk among RAS with the main vasodilator factors (prostaglandins E2 and I-2, bradykinin, atrial natriuretic factor, nitric oxide and adenosine) and the main vasoconstrictor factors (endothelin and vasopressin) in the ipsilateral kidney with UUO. In this review, the roles of the RAS on renal function and its interactions with the other factors in the kidney with UUO were discussed.

Item Type: Article
Hassanshahi, J.UNSPECIFIED
Nematbakhsh, M.UNSPECIFIED
Keywords: Renin-angiotensin system Unilateral ureteral obstruction Kidney injury Angiotensin II Angiotensin 1-7 renal interstitial fibrosis urinary-tract obstruction medullary collecting duct tubular epithelial-cells nitric-oxide deficiency chronic kidney-disease ii type-2 receptor at(2) receptors afferent arterioles natriuretic-peptide Physiology
Page Range: pp. 266-278
Journal or Publication Title: Physiology and Pharmacology
Journal Index: ISI
Volume: 21
Number: 4
ISSN: 2476-5236
Depositing User: مهندس مهدی شریفی

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