Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Prevention of type 2 diabetes mellitus by changes in diet among subjects with abnormal glucose metabolism: a randomized clinical trial

Wed Dec 7 07:29:58 2022

(2018) Prevention of type 2 diabetes mellitus by changes in diet among subjects with abnormal glucose metabolism: a randomized clinical trial. International Journal of Diabetes in Developing Countries. pp. 69-74. ISSN 0973-3930

Full text not available from this repository.

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

Previous studies demonstrated that changes in lifestyle slow the progression of impaired glucose tolerance to overt diabetes but few trials examined the effect of diet alone without weight loss on the prevention of diabetes. We investigated the efficacy of two types of diet with different macronutrients, on preventing or delaying the onset of type 2 diabetes in subjects with either impaired fasting glucose or impaired glucose tolerance. Three hundred and twenty-two subjects with prediabetes were randomly assigned to a high monounsaturated fat diet, normal fat diet, or control groups and followed for 2 years. For calculating the daily energy requirement in subjects with BMI >= 25 kg/m(2), the weight was adjusted with the use of 110 of the ideal body weight with no attempt for losing body weight. There was no difference in body weight decrease among the three groups after 2 years. The cumulative incidence of diabetes was 9.3 (95 CI, 3.6-14) in the high monounsaturated fat diet (HMD) group, 13.2 (95 CI, 6.4-19) in the normal fat diet (NFD) group, and 18.3 (95 CI, 10-25) in the control group. The cumulative incidence of diabetes was 57 lower in the HMD group than that in the control group (95 CI, 0.1-0.9; P = 0.03). This value was not significant in the NFD group (RR, 0.60; 95 CI, 0.2-1.2; P = 0.1). Type 2 diabetes can be prevented by a high-monounsaturated fat, low-carbohydrate diet and receiving energy based on the adjusted ideal body weight without a weight loss program. Trial registration number: NCT02250066.

Item Type: Article
Creators:
CreatorsEmail
Shahbazi, S.UNSPECIFIED
Shariatpanahi, Z. V.UNSPECIFIED
Keywords: Prediabetes Impaired fasting glucose Impaired glucose tolerance Monounsaturated fatty acid Olive oil life-style intervention fatty-acids carbohydrate diet tolerance metformin japanese risk igt Endocrinology & Metabolism
Divisions:
Page Range: pp. 69-74
Journal or Publication Title: International Journal of Diabetes in Developing Countries
Journal Index: ISI
Volume: 38
Number: 1
Identification Number: https://doi.org/10.1007/s13410-017-0548-3
ISSN: 0973-3930
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/181

Actions (login required)

View Item View Item