Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Lithium prevents cell apoptosis through autophagy induction

Fri May 24 10:04:20 2024

(2018) Lithium prevents cell apoptosis through autophagy induction. Bratislava Medical Journal-Bratislavske Lekarske Listy. pp. 234-239. ISSN 0006-9248

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OBJECTIVE: Bone marrow stromal stem cells (BMSCs) are widely used as an available source for cell therapy, tissue engineering, and cellular differentiation-based techniques. Therefore, it is necessary to apply a simple method through which BMSCs can be protected from cell apoptosis under tough conditions of cell differentiation. Lithium treatment is one of the simple methods in this regard. METHODS: The isolated BMSCs were divided into three groups: (a) control, (b) serum deprivation and (c) LiCl. Cell proliferation and apoptosis and autophagy markers in the presence and absence of LiCl were evaluated. RESULTS: LiCl has shown to increase survival rate of BMSCs under serum deprivation conditions through autophagy induction (reduced P62 and increased LC3II) and apoptosis inhibition (expression of XIAP), so that the cell survival rate, after 12 hours, was 29 , 59 , 83 , 74 , 49 for the groups, which received 0, 1, 5, 10, 20 millimolar of LiCl, respectively, as compared to the control group. CONCLUSION: LiCl leads to decreased apoptosis and increased survival rate through autophagy induction under serum deprivation conditions (Ref. 5, Ref. 37). Text in PDF

Item Type: Article
Keywords: lithium bone marrow stromal cells serum deprivation autophagy apoptosis mesenchymal stem-cells serum-deprivation transdifferentiation expression differentiation proliferation toxicity brain death vivo General & Internal Medicine
Page Range: pp. 234-239
Journal or Publication Title: Bratislava Medical Journal-Bratislavske Lekarske Listy
Journal Index: ISI
Volume: 119
Number: 4
Identification Number:₂₀₁₈₀₄₄
ISSN: 0006-9248
Depositing User: مهندس مهدی شریفی

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