Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

A Meta-Analysis of Prenatal and Maternal Risk Factors for Childhood Leukemia in Iran, Case-Control Studies Approach

Fri Apr 19 00:49:42 2024

(2018) A Meta-Analysis of Prenatal and Maternal Risk Factors for Childhood Leukemia in Iran, Case-Control Studies Approach. Journal of Pediatrics Review. p. 7. ISSN 2322-4398

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Abstract

Context: Few possible risk factors for childhood leukemia including environmental, genetic, and infectious causes can be explained by epidemiologic studies but the etiology of most childhood leukemia is unknown. Objectives: In this systematic review and meta-analysis, we aimed to find the relationship between prenatal and maternal risk factors with leukemia children in Iran. Data Sources: Relevant studies published in English databases (PubMed, Scopus, and ISI) and Persian databases (Magiran, Medlib, SID, and Iran Medex)) were systematically searched. Study Selection: The study included all case-control studies that estimated the effects of prenatal and maternal risk factors on leukemia children in Iran during years 2004 to 2016, and a standardized manner was used for the extraction of information. Data Extraction: After reviewing all searched articles (title, abstract, and entire text), irrelevant studies were excluded and related ones were selected. Results: We identified 10 case-control studies. The first relative history of leukemia was associated with four times raises of leukemia in children aged 15 > years (OR = 4.58, 95 CI = 1.16 - 7.99). Other significant risk factors were mothers with birth order 3 <= and maternal age > 35, ORs for these factors were respectively (OR = 2.39, 95 CI = 0.79 - 3.99) and OR = 2.25, 95 CI = 1.09 - 3.41). Conclusions: Our results indicate that among maternal and prenatal risk factors, birth order >= 3, birth weight < 2,500 g, and first relative history of leukemia increased the risk of childhood leukemia; in contrast, breastfeeding was a protective factor.

Item Type: Article
Creators:
CreatorsEmail
Veisani, Y.UNSPECIFIED
Delpisheh, A.UNSPECIFIED
Keywords: Child Leukemia Leukemia Leukemia Risk Factors Systematic Review birth characteristics association smoking children cancers cohort Pediatrics
Divisions:
Page Range: p. 7
Journal or Publication Title: Journal of Pediatrics Review
Journal Index: ISI
Volume: 6
Number: 1
Identification Number: https://doi.org/10.5812/jpr.14674
ISSN: 2322-4398
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/169

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