Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

On the mechanism of apoptosis-inducing activity of human calprotectin: Zinc sequestration, induction of a signaling pathway, or something else?

Thu Aug 11 15:18:10 2022

(2007) On the mechanism of apoptosis-inducing activity of human calprotectin: Zinc sequestration, induction of a signaling pathway, or something else? Medical Hypotheses. pp. 1012-1015. ISSN 03069877 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Calprotectin, a heterodimer present in neutrophil cytoplasm, has antimicrobial and apoptosis-inducing activities. At the moment, there are two general hypotheses about the mechanism of action of calprotectin: (i) exclusion of extracellular zinc by calprotectin, and consequently induction of apoptosis; (ii) binding of calprotectin to a cell membrane receptor, and consequently, activation of a signaling pathway for apoptosis. Here, we introduce another hypothesis, i.e. inhibition or destruction of "target" inside cells. We suggest that calprotectin might become internalized non-specifically, maybe in a process like pinocytosis. This process is probably independent of the zinc concentration. We also demonstrated that the internal target hypothesis successfully predicts cell survival behavior of cultured cells as a function of calprotectin concentration. Additional analyses should be performed to elucidate the real calprotectin "target". © 2006 Elsevier Ltd. All rights reserved.

Item Type: Article
Creators:
CreatorsEmail
Zali, H.UNSPECIFIED
Marashi, S. A.UNSPECIFIED
Rezaei-Tavirani, M.UNSPECIFIED
Toossi, P.UNSPECIFIED
Rahmati-Roodsari, M.UNSPECIFIED
Shokrgozar, M. A.UNSPECIFIED
Keywords: calprotectin membrane receptor zinc apoptosis article cell culture cell survival concentration (parameters) cytoplasm human inhibition kinetics neutrophil priority journal protein analysis protein targeting signal transduction Adenocarcinoma Cell Line, Tumor Dose-Response Relationship, Drug Humans Leukocyte L1 Antigen Complex Models, Biological Stomach Neoplasms Time Factors
Divisions:
Page Range: pp. 1012-1015
Journal or Publication Title: Medical Hypotheses
Journal Index: Scopus
Volume: 68
Number: 5
Identification Number: https://doi.org/10.1016/j.mehy.2006.09.056
ISSN: 03069877 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1677

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