Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Determination of free L-carnitine levels in type II diabetic women with and without complications

Sat Jul 20 21:38:48 2024

(2007) Determination of free L-carnitine levels in type II diabetic women with and without complications. European Journal of Clinical Nutrition. pp. 892-895. ISSN 09543007 (ISSN)

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Background: Studies on the determination of carnitine levels and nutritional status in patients of type II diabetes. Objective: We designed this study to determine changes of serum-free L-carnitine in type II diabetic women. Design: A cross-sectional study (case-control study). Setting: Clinicalof Endocrinology and Metabolism, Sina Hospital, Pharmacological Research Center, Tabriz Medical university, Iran. Patients and methods: Taking into account the importance of the control of diabetes, in the present case-control study, the levels of serum-free L-carnitine, blood glucose and lipids, systolic and diastolic blood pressure, body mass index (BMI) and nutritional status assessed in the case and control groups which were selected by the simple sampling method. The control group (n=18) included patients with no complications and the case group (n=33) was grouped into three subgroups including patients with retinopathy, hyperlipidemia and neuropathy. Results: Study results indicated that the mean serum-free L-carnitine concentration in the case group was significantly lower than its mean concentration level in the control group, 39.63±8.99 vs 53.42±0.93 μ/mol/l, respectively (P<0.001). Serum-free L-carnitine in retinopathy, hyperlipidemia and neuropathy case subgroups were 39.03±9.89, 39.63±8.99 and 40.44±12.50 μmol/ l, respectively (P>0.05). No significant difference was found between the serum-free carnitine levels of the case subgroups. The mean blood glucose, triglycerides, total cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol levels and systolic and diastolic blood pressure were significantly higher in the case group than in the control group. Conclusion: In this study, the mean serum-free L-carnitine levels in diabetic patients with complications was almost 25 lower than in diabetic patients with no complications. On the basis of the study results, carnitine supplementation in diabetic patients, especially in patients with diabetes complications, might be useful.

Item Type: Article
Aliasgarzadeh, A.UNSPECIFIED
Vahed Jabbari, M.UNSPECIFIED
Keywords: ascorbic acid carnitine cholesterol glucose iron lipid low density lipoprotein cholesterol lysine methionine nicotinamide nicotinic acid pyridoxine triacylglycerol very low density lipoprotein cholesterol adult article body mass concentration (parameters) controlled study cross-sectional study diabetic neuropathy diabetic retinopathy diastolic blood pressure diet supplementation female hospital based case control study human hyperlipidemia Iran major clinical study non insulin dependent diabetes mellitus nutritional status sampling systolic blood pressure university hospital Blood Glucose Blood Pressure Body Mass Index Case-Control Studies Cross-Sectional Studies Diabetes Complications Diabetes Mellitus, Type 2 Diabetic Neuropathies Humans Lipids Microcirculation Middle Aged
Page Range: pp. 892-895
Journal or Publication Title: European Journal of Clinical Nutrition
Journal Index: Scopus
Volume: 61
Number: 7
Identification Number:
ISSN: 09543007 (ISSN)
Depositing User: مهندس مهدی شریفی

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