Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Prenatal alcohol exposure, CYP17 gene polymorphisms and fetal growth restriction

Thu Jun 20 21:22:41 2024

(2008) Prenatal alcohol exposure, CYP17 gene polymorphisms and fetal growth restriction. European Journal of Obstetrics Gynecology and Reproductive Biology. pp. 49-53. ISSN 03012115 (ISSN)

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Objective: To determine the association of maternal CYP17 gene polymorphisms and prenatal alcohol consumption with intrauterine growth restriction (IUGR). Study design: A case-control study in singleton livebirths was conducted at the Liverpool Women's Hospital between 2004 and 2005. Cases (n = 90) were mothers with an IUGR baby and controls (n = 180) those with a normal birthweight infant. Maternal genomic DNA was extracted from buccal smears and PCR (RFLP) was used for genotyping. Results: Amongst cases, the prevalence of the maternal CYP17 homozygous wild type "A1A1", heterozygous "A1A2" and homozygous "A2A2" variants was 36.7, 47.7 and 15.6, which did not differ significantly from their prevalence amongst controls (p = 0.6). The proportion with prenatal alcohol exposure was significantly higher in cases than controls (45.6 versus 30.6, p = 0.01). Mean birthweight was significantly lower in mothers with the CYP17 A1A1 genotype compared to those with variant genotypes (A1A2/A2A2) in both the alcohol-exposed (p = 0.03) and non-exposed groups (p = 0.01). In all women regardless of genotype, IUGR risk increased in mothers exposed to alcohol during pregnancy (OR, 2.9, 95 CI; 1.8-4.2, p = 0.01). There was a significant interaction between the CYP17 A1A1 genotype and prenatal alcohol consumption for fetal growth restriction (adjusted OR, 1.4, 95 CI; 1.1-1.9, p = 0.04). Conclusion: The association between prenatal alcohol exposure and intrauterine fetal growth restriction was modulated by the maternal CYP17 A1A1 genotype. © 2007 Elsevier Ireland Ltd. All rights reserved.

Item Type: Article
Keywords: Alcohol CYP17 gene Fetal growth IUGR Liverpool cytochrome P450 17 genomic DNA alcohol consumption article birth weight cheek mucosa controlled study DNA extraction DNA polymorphism female genetic association genetic variability genotype heterozygosity homozygosity human infant intrauterine growth retardation live birth major clinical study polymerase chain reaction prenatal care prevalence priority journal risk factor Adolescent Adult Alcoholic Beverages Case-Control Studies Fetal Growth Retardation Genetic Predisposition to Disease Humans Infant, Newborn Infant, Small for Gestational Age Pregnancy Prenatal Exposure Delayed Effects Steroid 17-alpha-Hydroxylase
Page Range: pp. 49-53
Journal or Publication Title: European Journal of Obstetrics Gynecology and Reproductive Biology
Journal Index: Scopus
Volume: 138
Number: 1
Identification Number:
ISSN: 03012115 (ISSN)
Depositing User: مهندس مهدی شریفی

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