Repository of Research and Investigative Information

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Ilam University of Medical Sciences

A comparative study of inhibitory effect of human calprotectin on the growth of Human Gingival Fibroblast and Foreskin Fibroblast

Thu Oct 6 06:53:16 2022

(2008) A comparative study of inhibitory effect of human calprotectin on the growth of Human Gingival Fibroblast and Foreskin Fibroblast. Pakistan Journal of Biological Sciences. pp. 925-929. ISSN 10288880 (ISSN)

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Abstract

In the present study, cytotoxicity effects of calprotectin on Human Gingival Fibroblast (HGF) and Human Foreskin Fibroblast (HFFF) were compared. For these evaluations, both cells were exposed to the different concentrations of calprotectin, for 24, 48 and 72 h. Cell proliferation was assessed using MTT assay. Our results revealed that growth inhibition of calprotectin on HGF and HFFF occur in a dose- and time-dependent manner. Results of this investigation showed that sensitivity of HGF cells to cytotoxic effect of human calprotectin was more than HFFF. The results indicate that drug resistance process is different for the two kinds of fibroblast cells. © 2008 Asian Network for Scientific Information.

Item Type: Article
Creators:
CreatorsEmail
Rezaei-Tavirani, M.UNSPECIFIED
Zali, H.UNSPECIFIED
Nabai, L.UNSPECIFIED
Toossi, P.UNSPECIFIED
Zad, F. M.UNSPECIFIED
Pourkhoshbakht, Y.UNSPECIFIED
Keywords: Gingival and foreskin fibroblast cells Growth inhibition Human calprotectin calgranulin tetrazolium thiazole derivative thiazolyl blue article biological model cell line cell proliferation cell survival chemistry comparative study dose response drug effect fibroblast gingiva human male metabolism neutrophil prepuce sensitivity and specificity time Dose-Response Relationship, Drug Fibroblasts Foreskin Humans Leukocyte L1 Antigen Complex Models, Biological Neutrophils Tetrazolium Salts Thiazoles Time Factors
Divisions:
Page Range: pp. 925-929
Journal or Publication Title: Pakistan Journal of Biological Sciences
Journal Index: Scopus
Volume: 11
Number: 6
Identification Number: https://doi.org/10.3923/pjbs.2008.925.929
ISSN: 10288880 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1662

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