(2008) A comparative study of inhibitory effect of human calprotectin on the growth of Human Gingival Fibroblast and Foreskin Fibroblast. Pakistan Journal of Biological Sciences. pp. 925-929. ISSN 10288880 (ISSN)
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Abstract
In the present study, cytotoxicity effects of calprotectin on Human Gingival Fibroblast (HGF) and Human Foreskin Fibroblast (HFFF) were compared. For these evaluations, both cells were exposed to the different concentrations of calprotectin, for 24, 48 and 72 h. Cell proliferation was assessed using MTT assay. Our results revealed that growth inhibition of calprotectin on HGF and HFFF occur in a dose- and time-dependent manner. Results of this investigation showed that sensitivity of HGF cells to cytotoxic effect of human calprotectin was more than HFFF. The results indicate that drug resistance process is different for the two kinds of fibroblast cells. © 2008 Asian Network for Scientific Information.
| Item Type: | Article | ||||||||||||||
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| Keywords: | Gingival and foreskin fibroblast cells Growth inhibition Human calprotectin calgranulin tetrazolium thiazole derivative thiazolyl blue article biological model cell line cell proliferation cell survival chemistry comparative study dose response drug effect fibroblast gingiva human male metabolism neutrophil prepuce sensitivity and specificity time Dose-Response Relationship, Drug Fibroblasts Foreskin Humans Leukocyte L1 Antigen Complex Models, Biological Neutrophils Tetrazolium Salts Thiazoles Time Factors | ||||||||||||||
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| Page Range: | pp. 925-929 | ||||||||||||||
| Journal or Publication Title: | Pakistan Journal of Biological Sciences | ||||||||||||||
| Journal Index: | Scopus | ||||||||||||||
| Volume: | 11 | ||||||||||||||
| Number: | 6 | ||||||||||||||
| Identification Number: | https://doi.org/10.3923/pjbs.2008.925.929 | ||||||||||||||
| ISSN: | 10288880 (ISSN) | ||||||||||||||
| Depositing User: | مهندس مهدی شریفی | ||||||||||||||
| URI: | http://eprints.medilam.ac.ir/id/eprint/1662 |
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