Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Investigation of lipid profiles and lipid peroxidation in patients with type 2 diabetes

Wed Apr 17 06:39:39 2024

(2009) Investigation of lipid profiles and lipid peroxidation in patients with type 2 diabetes. European Journal of Scientific Research. pp. 6-13. ISSN 1450216X (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

The aim of this study was to investigat the lipid peroxidation of plasma as a marker of oxidant-induced protein damage the effects of oxygen radicals on glycated-hemoglobin and to find out the relationship between the increase level of Malondialdehyde (MDA) on HbA1C, lipid profiles and FBS (Fasting Blood Sugar) in patients with type 2 diabetes. This randomized study included 200 individuals, 100 cases had history of diabetic for at least 3 years (file in Isfehan hospital, Diabetic Center of Medical Sciences University) and 100 cases as the control group without history of diabetes. In both groups, level of MDA, FBS, lipid profiles and HbA1C were determined in fasting blood samples. Results showed that MDA level in diabetic patients was significantly (p<0.005) higher (0.9222 ± 0.3 μmol/L) than those in the control group (0.7428 ± 0.04μmol/L). The same was also true (p<0.05) for the level of HbA1C (9.387 ± 2.4 mg/dl in diabetic patients and 7.356 ± 1.0 mg/dl in the control group) and the FBS (163.31 ± 56mg/dl in patient group and 85.740 ± 10.1 in the control group). Furthermore, the concentration of, LDL significantly was higher (p<0.05) and the HDL level were significantly lower (p<0.05) in case group as compared to control group. The increased plasma lipid peroxidation and decreased plasma HDL that we observed in patients with type 2 diabetes mellitus indicated that these may predispose to the development of cardiovascular complications. © EuroJournals Publishing, Inc. 2009.

Item Type: Article
Creators:
CreatorsEmail
Hanachi, P.UNSPECIFIED
Moghadam, R. H.UNSPECIFIED
Latiffah, A. L.UNSPECIFIED
Keywords: FBS Lipid peroxidation Malondialdehyde
Divisions:
Page Range: pp. 6-13
Journal or Publication Title: European Journal of Scientific Research
Journal Index: Scopus
Volume: 28
Number: 1
ISSN: 1450216X (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1661

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