Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

A case-control study of CYP1A1, GSTT1 and GSTM1 gene polymorphisms, pregnancy smoking and fetal growth restriction

Thu Oct 6 08:52:11 2022

(2009) A case-control study of CYP1A1, GSTT1 and GSTM1 gene polymorphisms, pregnancy smoking and fetal growth restriction. European Journal of Obstetrics Gynecology and Reproductive Biology. pp. 38-42. ISSN 03012115 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Objectives: To determine the role of maternal CYP1A1, GSTT1, and GSTM1 metabolic gene polymorphisms in modulating the association between pregnancy smoking exposure and fetal growth restriction. Study design: A case-control study was conducted to investigate if the association of pregnancy smoking and birth outcome was modulated by maternal gene polymorphisms. A total of 90 mothers with an IUGR baby (cases) and 180 mothers without IUGR (controls) were enrolled. Results: Almost half of smokers who carried a CYP1A1 variant (51.3), GSTT1 null (43.6), or GSTM1 null genotypes (64.1) delivered a baby with IUGR. Smokers with the variant CYP1A1 "aa" genotype had babies with lower mean birthweight than non-smokers with the same genotype (p = 0.004). An interaction test showed increased prevalence of IUGR in smokers with the CYP1A1 (Aa/aa) variant (adjusted OR, 1.9; 95 CI, 1.4-5.5, p = 0.01), or with the GSTT1 null (AOR, 1.5; 1.1-3.1, p = 0.001), or GSTM1 null genotypes (AOR, 1.5; 1.2-3.7, p = 0.001). Conclusions: Risk of fetal growth restriction in mothers who smoked during pregnancy was modulated by maternal metabolic gene polymorphisms. The genetic control of the conversion of toxic metabolites of tobacco smoke to less damaging substances is important for maternal and fetal health. © 2008 Elsevier Ireland Ltd. All rights reserved.

Item Type: Article
Creators:
CreatorsEmail
Delpisheh, A.UNSPECIFIED
Brabin, L.UNSPECIFIED
Topping, J.UNSPECIFIED
Reyad, M.UNSPECIFIED
Tang, A. W.UNSPECIFIED
Brabin, B. J.UNSPECIFIED
Keywords: Genetic IUGR Pregnancy Smoking cytochrome P450 1A1 glutathione transferase M1 glutathione transferase T1 article birth weight controlled study DNA polymorphism female genetic variability genotype human intrauterine growth retardation prevalence priority journal Case-Control Studies Cytochrome P-450 CYP1A1 Fetal Growth Retardation Glutathione Transferase Humans Polymorphism, Genetic Risk Factors
Divisions:
Page Range: pp. 38-42
Journal or Publication Title: European Journal of Obstetrics Gynecology and Reproductive Biology
Journal Index: Scopus
Volume: 143
Number: 1
Identification Number: https://doi.org/10.1016/j.ejogrb.2008.11.006
ISSN: 03012115 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1659

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