(2009) Predictive factors of survival time after hematopoietic stem cell transplant in acute myeloid leukemia patients who received allogeneic BMT from matched sibling donors using Generalized Gamma models. International journal of hematology-oncology and stem cell research. pp. 21-26. ISSN 17351243 (ISSN)
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Abstract
Introduction: This paper used Generalized Gamma (GG) distribution to find the predictive factors of overall survival (OS) after haematopoietic stem cell transplant (HSCT) in acute myeloid leukemia patients. Methods: Discrimination among the exponential, Weibull, GG, log-logistic, and lognormal distributions was done using maximum likelihood and Akaike information criteria. Results: The 5-year OS in 301 patients was 65 (95CI: 60.7-69.3). Peak mortality hazard occurred at months 6-7 after HSCT then, it was U Shape. The data was fitted by GG distribution better than other distributions. Univariate analysis using GG distribution showed a positive association between OS with dose of infused WBC (P=0.018), CD3 (p=0.001), no relapse (P<0.001), cGVHD (P<0.001), and platelet recovery (P<0.001). Multivariate analysis indicated that, OS has relationship with relapse (P<0.001), platelet recovery (P=0.004), disease status at transplant (P=0.036) and aGVHD (P=0.036). Conclusion: We showed that GG distribution can be a useful tool for recognizing prognostic factors of OS in AML patients.
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| Keywords: | Acute myeloid leukaemia Generalized gamma distribution Prognostic factors Survival analysis busulfan cyclophosphamide cyclosporin methotrexate acute granulocytic leukemia adolescent adult aged allogenic bone marrow transplantation article bone marrow transplantation child continuous infusion controlled study drug dose reduction female generalized gamma model graft versus host reaction hematopoietic stem cell transplantation HLA matching human leukemia relapse major clinical study male multiple cycle treatment overall survival parametric test peripheral blood stem cell transplantation preschool child prognosis risk assessment risk factor school child survival rate survival time | ||||||||||||||||||||
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| Page Range: | pp. 21-26 | ||||||||||||||||||||
| Journal or Publication Title: | International journal of hematology-oncology and stem cell research | ||||||||||||||||||||
| Journal Index: | Scopus | ||||||||||||||||||||
| Volume: | 3 | ||||||||||||||||||||
| Number: | 1 | ||||||||||||||||||||
| ISSN: | 17351243 (ISSN) | ||||||||||||||||||||
| Depositing User: | مهندس مهدی شریفی | ||||||||||||||||||||
| URI: | http://eprints.medilam.ac.ir/id/eprint/1654 |
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