Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Effect of exogenous Ghrelin on lipopolysaccharide induced change livers enzyme level in rats

Sun Jun 16 05:11:49 2024

(2011) Effect of exogenous Ghrelin on lipopolysaccharide induced change livers enzyme level in rats. Journal of Babol University of Medical Sciences. pp. 35-41. ISSN 15614107 (ISSN)

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BACKGROUND AND OBJECTIVE: Bacterial lipopolysaccharide (LPS) is a component of the gram-negative bacterial cell wall and is believed to mediate many of the sequela of infection. The liver plays a central role in the inflammatory response to LPS. Elevation of livers enzyme level is one of changes induced in acute phase of inflammation by infection or tissue damage. Ghrelin is a peptide hormone mainly secreted by the mucosa of the stomach and stimulates growth hormone release. Based on anti-inflammatory effects of Ghrelin, in this study we examined the protective effect of Ghrelin on lipopolysaccharide-induced hepatotoxicity in rat. METHODS: In this study forty male Wistar rats (200-250 g) were randomly divided into 4 groups (N=10). Control group received normal saline, second group received LPS (10 mg/kg body weight, i.p), third group received Ghrelin (4 nmol/kg, i.p), and forth group received LPS + Ghrelin (10 mg/kg and 4nmol/kg, respectively) for 8 days. At the end of the 8th day, animals were anaesthetized and blood samples were collected directly from heart. Hepatotoxicity was evaluated by measuring aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma-glutamyl-transpeptidase (GGT). FINDINGS: Injection of LPS induced a significant increase in AST, ALT, ALP and GGT compared with control group (p<0.001). LPS- induced increases in AST, ALT, ALP and GGT were significantly reduced by treatment with Ghrelin (p<0.001). CONCLUSION: In conclusion, our results suggest that Ghrelin has protective effect against LPS- induced hepatotoxicity and this effect may be mediated by anti inflammatory effect of Ghrelin.

Item Type: Article
Ebrahimi Vosta Kalai, S.UNSPECIFIED
Keywords: Ghrelin Hepatotoxicity Lipopolysaccharide Liver enzymes alanine aminotransferase alkaline phosphatase aspartate aminotransferase gamma glutamyltransferase alanine aminotransferase blood level alkaline phosphatase blood level animal experiment animal model antiinflammatory activity article aspartate aminotransferase blood level controlled study drug efficacy drug safety gamma glutamyl transferase blood level liver protection liver toxicity male nonhuman rat treatment response
Page Range: pp. 35-41
Journal or Publication Title: Journal of Babol University of Medical Sciences
Journal Index: Scopus
Volume: 13
Number: 3
Identification Number:; Katergari, S.A., Milousis, A., Pagonopoulou, O., Asimakopoulos, B., Nikolettos, N.K., Gherlin in pathological conditions (2008) Endoc J, 55 (3), pp. 439-453; Tesauro, M., Schinzari, F., Rovella, A., Gherlin restores the endothelin 1/n
ISSN: 15614107 (ISSN)
Depositing User: مهندس مهدی شریفی

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