Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Beneficial effects of artichoke on liver phosphatidate phosphohydrolase and plasma lipids in rats fed by lipogenic diet

Tue Jul 5 17:12:31 2022

(2011) Beneficial effects of artichoke on liver phosphatidate phosphohydrolase and plasma lipids in rats fed by lipogenic diet. International Journal of Phytomedicine. pp. 285-293. ISSN 09750185 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Artichoke (Cynara scolymus L.) is full of natural antioxidants and has a lipid-lowering effect. The aim of this study was to investigate the effect of artichoke on the liver phosphatidate phosphohydrolase, plasma lipid levels, plasma malondialdehyde, and plasma antioxidant in rats fed by lipogenic diet. Male rats were fed by standard pellet diet (group I), standard diet supplemented with 10 artichoke (group II), lipogenic diet (containing sunflower oil, cholesterol and ethanol) plus 10 artichoke (group III) and only lipogenic diet (group IV). On day 60 of the experiment, liver phosphatidate phosphohydrolase activity, liver triglyceride, plasma lipids, plasma malondialdehyde, and plasma antioxidant levels were measured. Phosphatidate phosphohydrolase activity, liver triglyceride, the ratio of total cholesterol to high density lipoprotein cholesterol, plasma total cholesterol and triglyceride levels were significantly decreased due to artichoke treatment in groups II and III compared to groups I and IV, respectively. Significant reduction in plasma malondialdehyde and significant elevation in plasma antioxidant power observed in groups II and III compared to groups I and IV, respectively. The results clearly indicated that artichoke can be useful for the reduction of phosphatidate phosphohydrolase activity and liver triglyceride. Also, artichoke has beneficial effects in the controlling of hyperlipidemia, abnormalities in lipid profiles and oxidative stress in hyperlipidemic regimes.

Item Type: Article
Creators:
CreatorsEmail
Heidarian, E.UNSPECIFIED
Jafari-Dehkordi, E.UNSPECIFIED
Seidkhani-Nahal, A.UNSPECIFIED
Keywords: Artichoke Hypercholesterolemia Liver triglyceride Phosphatidate phosphohydrolase Plasma lipids herbaceous agent high density lipoprotein cholesterol malonaldehyde phosphatidate phosphatase triacylglycerol animal experiment animal model animal tissue article cholesterol blood level controlled study drug mechanism enzyme activity hyperlipidemia lipid composition male nonhuman oxidative stress rat triacylglycerol blood level
Divisions:
Page Range: pp. 285-293
Journal or Publication Title: International Journal of Phytomedicine
Journal Index: Scopus
Volume: 3
Number: 2
ISSN: 09750185 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1614

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