Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Prevalence of OmpK35 and OmpK36 porin expression in beta-lactamase and non-beta-lactamase-producing Klebsiella pneumoniae

(2012) Prevalence of OmpK35 and OmpK36 porin expression in beta-lactamase and non-beta-lactamase-producing Klebsiella pneumoniae. Biologics: Targets and Therapy. pp. 1-4. ISSN 11775475 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background: The aims of this study were to confirm the presence of OmpK35 and OmpK36 in extended-spectrum beta-lactamase-producing and nonextended-spectrum beta-lactamase-producing Klebsiella pneumoniae and to determine the relationship between porin expression and resistance to third-generation cephalosporins. Methods: Fifty-two K. pneumoniae isolates were obtained and analyzed for extended-spectrum beta-lactamase and for OmpK35 and OmpK36. Results: Twenty-two (42.3) isolates of K. pneumoniae were extended-spectrum beta-lactamase producers. The OmpK35 profile in K. pneumoniae producing extended-spectrum beta-lactamase showed the presence of porin protein in ceftazidime-sensitive K. pneumoniae (six isolates), and the OmpK36 profile in K. pneumoniae producing extended-spectrum beta-lactamase revealed isolates sensitive to cefotaxime (n = 8) and ceftriaxone (n = 6). All nonextended-spectrum beta-lactamase-producing K. pneumoniae showed the presence of OmpK35 and OmpK36 porin proteins. Conclusion: The presence of OmpK35 is mostly related to ceftazidime susceptibility and less to cefotaxime and ceftriaxone susceptibility, while OmpK36 expression is seen more often in cefotaxime-sensitive isolates. OmpK35 and OmpK36 indicate nonextended-spectrum beta-lactamase producing strains, and their presence is important when selecting an antimicrobial agent. © 2012 Shakib et al.

Item Type: Article
Keywords: Extended-spectrum beta-lactamase producing strains Klebsiella pneumoniae Porin expression antiinfective agent beta lactamase cefotaxime ceftazidime ceftriaxone cephalosporin OmpK35 porin OmpK36 porin porin unclassified drug antibiotic resistance antibiotic sensitivity article bacterial strain bacterium isolate controlled study drug choice extended spectrum beta lactamase producing Klebsiella pneumoniae non extended spectrum beta lactamase producing Klebsiella pneumoniae nonhuman protein expression
Page Range: pp. 1-4
Journal or Publication Title: Biologics: Targets and Therapy
Journal Index: Scopus
Volume: 6
ISSN: 11775475 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1603

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