Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Association between HDL particles size and myeloperoxidase/ paraoxonase-1 (MPO/PON1) ratio in patients with acute coronary syndrome

Sun Aug 14 01:06:54 2022

(2013) Association between HDL particles size and myeloperoxidase/ paraoxonase-1 (MPO/PON1) ratio in patients with acute coronary syndrome. Acta medica Iranica. pp. 365-371. ISSN 00446025 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Myeloperoxidase (MPO) and paraoxonase-1 (PON1) are inflammatory and anti-inflammatory enzymes, respectively that have been involved in the pathogenesis of coronary artery disease (CAD). In this study we sought to evaluate the relations of MPO and PON1 with high density lipoprotein (HDL) mean size in patients with acute coronary syndrome (ACS). Collectively, 50 control subjects and 50 patients with ACS were participated in this study. MPO level and PON1 activity was determined using immunoassay and colorimetric methods, respectively. HDL mean size was determined by a dynamic light scattering methodology. Other clinical risk factors were also determined by standard methods. The MPO/PON1 ratio amount was significantly higher in patients with ACS (1.49±1.10) than in control subjects (0.21±0.14) (P<0.01). There was a significant correlation between MPO/PON1 ratio and HDL mean size in patients with ACS. Amount of the enzymes and their relations to HDL particle size in patients with ACS may play a part in the pathogenesis of ACS. Also, MPO/PON1 ratio may be a robust predictor of ACS. © 2013 Tehran University of Medical Sciences. All rights reserved.

Item Type: Article
Creators:
CreatorsEmail
Razavi, A. E.UNSPECIFIED
Basati, G.UNSPECIFIED
Varshosaz, J.UNSPECIFIED
Abdi, S.UNSPECIFIED
Keywords: HDL mean size Myeloperoxidase Paraoxonase-1 aryldialkylphosphatase 1 C reactive protein high density lipoprotein high density lipoprotein cholesterol low density lipoprotein cholesterol aryldialkylphosphatase biological marker peroxidase PON1 protein, human acute coronary syndrome adult angiography article body mass cardiovascular risk chemical analysis cholesterol blood level clinical article colorimetry controlled study diabetes mellitus female human hypertension immunoassay light scattering male particle size pathogenesis smoking blood chemistry comparative study follow up middle aged prognosis risk factor Biological Markers Follow-Up Studies Humans Lipoproteins, HDL Risk Factors
Divisions:
Page Range: pp. 365-371
Journal or Publication Title: Acta medica Iranica
Journal Index: Scopus
Volume: 51
Number: 6
ISSN: 00446025 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1588

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