Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The possible role of TLR2 in chronic hepatitis B patients with precore mutation

Sun Aug 14 02:02:48 2022

(2013) The possible role of TLR2 in chronic hepatitis B patients with precore mutation. Advances in Virology. ISSN 16878639 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Recognition mechanisms of innate immune response help to improve immunotherapeutic strategies in HBeAg-negative chronic hepatitis B (CHB). Toll-like receptor 2 (TLR2) is an important component of innate immunity. In this study, the frequency of precore mutations of the hepatitis B virus (HBV) and serum TLR2 were evaluated in CHB patients. Fifty-one patients with chronic hepatitis B, negative for HBeAg and detectable HBV DNA, were examined for the presence of mutations in pre-core region of HBV genome by direct sequencing. Serum TLR2 was measured by enzyme-linked immunosorbent assay. Interactions of truncated HBeAg and TLR2 proteins were evaluated with molecular docking software. The G1896A pre-core mutation were detected in 29 (57) which was significantly associated with higher concentration of serum TLR2 in comparison with patients without this mutation (4.8 ± 2.9 versus 3.4 ± 2.2 ng/mL, P = 0.03). There was also a significant correlation between serum ALT and TLR-2 (r = 0.46; P = 0.01). Docking results illustrated residues within the N-terminus of truncated HBeAg and TLR2, which might facilitate the interaction of these proteins. These findings showed the dominance of G1896A pre-core mutation of HBV variants in this community which was correlated with serum TLR2. Moreover TLR2 is critical for induction of inflammatory cytokines and therefore ALT elevation. © 2013 Malihe Moradzadeh et al.

Item Type: Article
Creators:
CreatorsEmail
Moradzadeh, M.UNSPECIFIED
Tayebi, S.UNSPECIFIED
Poustchi, H.UNSPECIFIED
Sayehmiri, K.UNSPECIFIED
Shahnazari, P.UNSPECIFIED
Naderi, E.UNSPECIFIED
Montazeri, G.UNSPECIFIED
Mohamadkhani, A.UNSPECIFIED
Divisions:
Journal or Publication Title: Advances in Virology
Journal Index: Scopus
Volume: 2013
Identification Number: https://doi.org/10.1155/2013/780319
ISSN: 16878639 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1554

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