Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Ethanol-induced chromosomal abnormalities in human fibroblast cells

Wed Jun 19 01:13:18 2024

(2014) Ethanol-induced chromosomal abnormalities in human fibroblast cells. Koomesh. pp. 254-259. ISSN 16087046 (ISSN)

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Introduction: ethanol consumption may impose cytotoxic effects on the human body, by producing toxic metabolites through different pathways. Furthermore, some studies have also linked alcohol consumption to various types of diseases. Therefore, this in vitro study is aimed to assess the ethanol toxic effects on the human fibroblastic chromosome structure. Materials and Methods: G banding staining method was used to determine the karyotype of chromosomal abnormalities of cultured fibroblast cells. Karyogram of ethanol-treated cells after 48 hours of incubation with 54 and 108 mmol of ethanol were assessed against the untreated cultured cells. Results: the comparison between two karyogram models confirmed that lower ethanol concentration (54mmol) caused breakage in chromosome type C and number 1, while with higher concentration (108mmol) breakage was observed in chromosome 9, chromatids as well as endoreplication in some other cells. Conclusion: this study indicates that specific concentrations of ethanol can cause vast alterations in chromosomal structure. Therefore, in general, more care is suggested in consuming this substance. In addition, to confirm the cytotoxic alterations in chromosomal structure in relation to alcohol consumption, using other cell lines and /or in vivo studies, more investigations are warrant. © 2014, Semnan University of Medical Sciences. All rights reserved.

Item Type: Article
Zamanian-Azodi, M.UNSPECIFIED
Reza Akbari Eidgahi, M.UNSPECIFIED
Keywords: Chromosome abnormalities Ethanol Human fibroblast cell Karyotype
Page Range: pp. 254-259
Journal or Publication Title: Koomesh
Journal Index: Scopus
Volume: 16
Number: 2
ISSN: 16087046 (ISSN)
Depositing User: مهندس مهدی شریفی

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