Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Metabolic syndrome and its components among women with polycystic ovary syndrome: a systematic review and meta-analysis

(2018) Metabolic syndrome and its components among women with polycystic ovary syndrome: a systematic review and meta-analysis. Journal of Cardiovascular and Thoracic Research. pp. 56-69. ISSN 2008-5117

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Abstract

Introduction: The objectives of this study were to provide an estimate of the prevalence of metabolic syndrome (MetS) and its components among women with PCOS; and calculate the odds ratio (OR) for MetS (using different definitions of MetS) in women with PCOS, compared to healthy controls. Methods: All of the relevant databases were used to search for appropriate articles that were published during the period 2003-2016. We included observational studies (cross-sectional, comparative cross-sectional) among women who met the inclusion criteria. The random-effect models were used to pool the prevalence of MetS and its components among PCOS women. This model was also applied to the pooled OR assessing the association between MetS and PCOS. Results: The pooled prevalence of MetS among PCOS women was found to be 26.30 (95 CI: 23.68-28.93), but varied from 7.10 (95 CI: 1.64-12.56) to 37.50 (95 CI: 28.84-46.16), depending upon the diagnostic criteria used. Low high-density lipoprotein cholesterol (HDL)-61.87 (95 CI: 53.31-70.43) and high waist circumference (WC)-52.23 (95 CI: 43.84-60.61) were the most common components of MetS in PCOS women. Compared to healthy controls, the overall pooled (OR) of MetS in PCOS patients was 2.09 (95 CI: 1.67-2.60), but this ranged from 0.31 (95 CI: 0.13-0.74) to 4.69 (95 CI: 2.09-10.52), depending upon the diagnostic criteria used. Conclusion: Women with PCOS had a much higher prevalence of MetS than was found among the healthy controls. Furthermore, as low HDL and high WC were the most common components of MetS in PCOS women, these two components specifically need to be addressed in prevention strategies.

Item Type: Article
Keywords: Global Metabolic Syndrome Prevalence Polycystic Ovary Syndrome Meta-Analysis international-diabetes-federation obese women iii definitions young-women atp-iii prevalence criteria risk association disease Cardiovascular System & Cardiology
Divisions:
Page Range: pp. 56-69
Journal or Publication Title: Journal of Cardiovascular and Thoracic Research
Journal Index: ISI
Volume: 10
Number: 2
Identification Number: https://doi.org/10.15171/jcvtr.2018.10
ISSN: 2008-5117
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/155

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