Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Using phage as a highly specific antibiotic alternative against Methicillin Resistance Staphylococcus aureus (MRSA)

Mon Aug 8 18:53:21 2022

(2014) Using phage as a highly specific antibiotic alternative against Methicillin Resistance Staphylococcus aureus (MRSA). Biosciences Biotechnology Research Asia. pp. 523-529. ISSN 09731245 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Misuse of antibiotics in humans and animals often leads to the development ofmultidrug resistance (MDR)bacteria. Resistance can occur within a few years of novel antibiotics being introduced. Lytic bacteriophage (phage) are a kind of virus that undergo a cyclical lifestyle wherein they infect and replicate through the use of a bacterial host cell and cause cell lysis. Phage recognizes specific receptors on their host cell to attach to, insert their DNA and take over their host's molecular machinery. These receptors only exist on the surface of specific bacterial host cells and are often not present on other non-specific bacteria and not especially on the surfaces of eukaryotic cells. The mechanisms by which phage can destroy bacteria are different from antibiotics; phage can lyse MDR resistant bacteria without being affected by hydrolytic enzymes or ribosomal variations that's mean unlike drug resistance mechanism which bacteria can destroy the drug before can inter the bacteria cell, the phage not effected with such enzyme.

Item Type: Article
Creators:
CreatorsEmail
Rezaei, F.UNSPECIFIED
Nasser, A.UNSPECIFIED
Jalilian, F. A.UNSPECIFIED
Hobbs, Z.UNSPECIFIED
Azizian, R.UNSPECIFIED
Keywords: Antibiotics Human and animals MRSA antibiotic agent antibiotic resistance antibiotic therapy Article bacteriophage cytolysis eukaryotic cell genetic engineering host cell human methicillin resistant Staphylococcus aureus molecular mechanics nonhuman protein hydrolysis surface property virus infection virus replication Animalia Bacteria (microorganisms) Eukaryota Staphylococcus aureus
Divisions:
Page Range: pp. 523-529
Journal or Publication Title: Biosciences Biotechnology Research Asia
Journal Index: Scopus
Volume: 11
Number: 2
Identification Number: https://doi.org/10.13005/bbra/1302
ISSN: 09731245 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1542

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