Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Differential between multi-drug resistance pattern of extended spectrum β-lactamases producing E. coli and K. pneumoniae

Mon Jun 27 10:58:28 2022

(2014) Differential between multi-drug resistance pattern of extended spectrum β-lactamases producing E. coli and K. pneumoniae. Journal of Pure and Applied Microbiology. pp. 85-89. ISSN 09737510 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

The current study aimed to determine the prevalence of Extended-Spectrum β-Lactamases (ESBLs) in Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) strains isolated from patients with Urinary Tract Infections (UTIs), to study the association between presence of ESBL enzyme and multi-drug resistance strains and finally, and to investigate the predominant ESBL gene in E. coli and K. pneumoniae. The strains were examined for the presence of ESBL as a Clinical Laboratory Standards Institute (CLSI) guideline. Among 284 clinical isolates, 52.8 (n = 150) and 47.2 (n =134) were E. coli and K. pneumoniae, respectively, and 110 strains were ESBL producer, which 68 strains were K. pneumoniae and 42 strains were E. coli. Significant difference observed between the TEM gene and ciprofloxacin resistant in E. coli (P ≤ 0.05) while no significant difference observed between CTX-M, SHV genes and the other multi-drug resistant E. coli. No significant difference observed between CTX-M, TEM, and SHV genes and multi-drug resistant K. pneumoniae. In conclusion, spreading of ESBL-producing strains is a concern, as it causes limitations to the antimicrobial agents for optimal treatment of patients. Prevalence of ESBLs was more observed in K. pneumoniae than E. coli. In addition, TEM gene was more prevalent in E. coli and resistance to ciprofloxacin was predominant in E. coli.

Item Type: Article
Creators:
CreatorsEmail
Ghafourian, S.UNSPECIFIED
Soheili, S.UNSPECIFIED
Aboualigalehdari, E.UNSPECIFIED
Sadeghifard, N.UNSPECIFIED
Mohebi, R.UNSPECIFIED
Maleki, A.UNSPECIFIED
Hamat, R. A.UNSPECIFIED
Hosseini, S.UNSPECIFIED
Sekawi, Z.UNSPECIFIED
Keywords: ESBLs Multi-drug resistant Urinary tract infection
Divisions:
Page Range: pp. 85-89
Journal or Publication Title: Journal of Pure and Applied Microbiology
Journal Index: Scopus
Volume: 8
Number: SPEC.
ISSN: 09737510 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/1540

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