Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Association of rs7903146, rsl2255372, and rs290487 polymorphisms in TCF7L2 gene with type 2 diabetes in an Iranian Kurdish Ethnic Group

Wed Jul 24 09:27:54 2024

(2014) Association of rs7903146, rsl2255372, and rs290487 polymorphisms in TCF7L2 gene with type 2 diabetes in an Iranian Kurdish Ethnic Group. Clinical Laboratory. pp. 1269-1276. ISSN 14336510 (ISSN)

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Single nucleotide polymorphisms (SNPs) within the transcription factor 7-like 2 (TCF7L2) gene are well known risk variants for type 2 diabetes mellitus (T2DM). The association between TCF7L2 SNPs and T2DM has been investigated in several studies, but the results are controversial. In this study, we investigated whether the rs7903146, rsl2255372, and rs290487 polymorphisms of TCF7L2 are associated with T2DM per se or metabolic traits related to this disease in a Kurdish ethnic group of Iran. Methods: In all, 173 patients with T2DM and 173 normoglycemic subjects were included in this study. All subjects were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Geno-typic and allelic frequencies were then analyzed in each group. Serum lipids, fasting glucose, fasting serum insulin, HOMA-IR, and HbA1c levels were determined by conventional methods. Results: T-allele and genotype frequencies of rs7903146, rs12255372, and rs290487 were significantly different between T2DM and control subjects. The CT genotype (OR = 1.98, p = 0.008), TT genotype (OR = 3.54, p = 0.024), and the dominant model (OR = 2.16, p = 0.002) of rs7903146 were associated with T2DM. The GT genotype (OR = 2.23, p = 0.005), TT genotype (OR = 4.25, p = 0.046), and the dominant model (OR = 2.2, p = 0.001) of rsl2255372 gave a higher risk for T2DM. The carriers of CT genotype of rs290487 showed a significantly increased risk for T2DM (OR = 2.24, p = 0.003). Similarly, the dominant model of this SNP was found to be significantly associated with T2DM (OR = 2.25, p = 0.002). The control subjects carrying the T-allele of rs7903146 had higher levels of total cholesterol (CC; 4.52 ± 1.03 vs. CT + TT; 5.00 ± 1.2 mmol/L, p = 0.009) than those with CC genotype. Normoglycemic subjects carrying GT + TT genotypes of rsl2255372 had a significantly higher WHR (GG; 0.90 ± 0.059 vs. GT + TT; 0.93 ± 0.07, p = 0.038) as compared with those with the GG genotype. Conclusions: The T-allele of rsl2255372, rs7903146, and rs290487 polymorphisms of TCF7L2 confer susceptibility to T2DM in the Kurdish population of Iran.

Item Type: Article
Keywords: Kurd Polymorphism TCF7L2 Type 2 diabetes cholesterol glucose hemoglobin A1c insulin lipid TCF7L2 protein, human transcription factor 7 like 2 adult anthropometric parameters article cholesterol blood level controlled study ethnic group female gene gene frequency genetic association genetic variability genotype glycemic control human insulin blood level Iran Kurd (people) lipid blood level major clinical study male non insulin dependent diabetes mellitus quantitative trait single nucleotide polymorphism TCF7L2 gene aged allele anthropometry ethnology genetic predisposition genetics glucose blood level middle aged polymerase chain reaction restriction fragment length polymorphism Alleles Blood Glucose Diabetes Mellitus, Type 2 Genetic Predisposition to Disease Humans Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide Transcription Factor 7-Like 2 Protein
Page Range: pp. 1269-1276
Journal or Publication Title: Clinical Laboratory
Journal Index: Scopus
Volume: 60
Number: 8
Identification Number:
ISSN: 14336510 (ISSN)
Depositing User: مهندس مهدی شریفی

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